Geranyltranstransferase (PA4043)

Identification
Name: Geranyltranstransferase
Synonyms:
  • Farnesyl-diphosphate synthase
  • FPP synthase
Gene Name: ispA
Enzyme Class:
Biological Properties
General Function: Involved in isoprenoid biosynthetic process
Specific Function: Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb
Dimethylallylpyrophosphate + Isopentenyl pyrophosphate → Geranyl-PP + Pyrophosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Geranyl-PP + Isopentenyl pyrophosphate + Geranyl diphosphate ↔ Farnesyl pyrophosphate + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
Dimethylallylpyrophosphate + Isopentenyl pyrophosphate ↔ Pyrophosphate + Geranyl-PP
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Thumb+Thumb ↔ Thumb+Thumb
Geranyl-PP + Isopentenyl pyrophosphate ↔ Pyrophosphate + Farnesyl pyrophosphate
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SMPDB Reactions:
Dimethylallylpyrophosphate+Isopentenyl pyrophosphate+Thumb+Thumb → Pyrophosphate+Geranyl-PP+Thumb
Dimethylallylpyrophosphate + Isopentenyl pyrophosphate + Dimethylallylpyrophosphate + Isopentenyl pyrophosphate → Pyrophosphate + Geranyl-PP + Geranyl-PP
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Geranyl-PP+Isopentenyl pyrophosphate+Thumb+Thumb → Pyrophosphate+Farnesyl pyrophosphate+Thumb
Geranyl-PP + Isopentenyl pyrophosphate + Geranyl-PP + Isopentenyl pyrophosphate → Pyrophosphate + Farnesyl pyrophosphate + Farnesyl pyrophosphate
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
Dimethylallylpyrophosphate + Isopentenyl pyrophosphate → Geranyl-PP + Pyrophosphate
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Thumb+Thumb+Thumb ↔ Thumb+Thumb
Geranyl-PP + Isopentenyl pyrophosphate + Geranyl diphosphate ↔ Farnesyl pyrophosphate + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
Dimethylallylpyrophosphate + Isopentenyl pyrophosphate ↔ Pyrophosphate + Geranyl-PP
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Thumb+Thumb ↔ Thumb+Thumb
Geranyl-PP + Isopentenyl pyrophosphate ↔ Pyrophosphate + Farnesyl pyrophosphate
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Thumb+Thumb → Thumb+Thumb
Geranyl-PP + Isopentenyl pyrophosphate → Farnesyl pyrophosphate + Pyrophosphate
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Thumb+Thumb → Thumb+Thumb
Dimethylallylpyrophosphate + Isopentenyl pyrophosphate → Geranyl-PP + Pyrophosphate
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Geranyl-PP + Isopentenyl pyrophosphate → Pyrophosphate + Farnesyl pyrophosphate
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000260DimethylallylpyrophosphateMetaboCard
PAMDB000210Farnesyl pyrophosphateMetaboCard
PAMDB003527Geranyl diphosphateMetaboCard
PAMDB000324Geranyl-PPMetaboCard
PAMDB000348Isopentenyl pyrophosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Process
cellular lipid metabolic process
isoprenoid biosynthetic process
isoprenoid metabolic process
lipid metabolic process
metabolic process
primary metabolic process
Gene Properties
Locus tag: PA4043
Strand: +
Entrez Gene ID: 879058
Accession: NP_252732.1
GI: 15599238
Sequence start: 4525551
Sequence End: 4526438
Sequence Length: 887
Gene Sequence: 
>PA4043
ATGATCGCGGCCTACCAGGCGCGCTGCCAGGCGCGCGTCGATGCCGCCCTGGACGCCCTGTTCGTCGCTCCCCGCGAAGAACTGCAACGCCTCTACGAGGCCATGCGCTACAGCGTGATGAACGGTGGCAAGCGGGTTCGCCCGCTGCTCGCCTACGCCGCCTGCGAGGCCCTCGGCGGAGCGCCGCAGCGCGCCGACGCCGCGGCCTGCGCGGTGGAGCTGATCCATGCCTACTCGCTGGTCCACGACGACCTGCCGGCGATGGACGACGACGACCTGCGCCGTGGCCAGCCGACCACCCACCGGGCCTTCGACGAAGCCACCGCGATCCTCGCCGCCGACGGCTTGCAGGCGCTGGCCTTCGAAGTGCTCGCCGACACCCGGCGCAATCCGCAGGAACATGCCGTCTGTCTGGAAATGCTCACCCGCCTGGCGCGCGCCGCAGGCTCCGCCGGCATGGTCGGCGGCCAGGCGATCGACCTCGGCTCGGTCGGCGTGGCCCTCGACCAGGCGGCCCTGGAAGTCATGCACCGGCACAAGACCGGCGCGCTGATCGAAGCCAGCGTGCGCCTCGGCGCCCTCGCCAGCGGTCGCGCCGAGCCCGCCTCGCTGGCCGCCCTGGAGCGCTACGCCGAAGCGATCGGCCTGGCCTTCCAGGTGCAGGACGACATCCTCGACGTGGAAAGCGACACCGCCACCCTCGGCAAGACCCAGGGCAAGGACCAGGCGCACAACAAGCCGACCTATCCCGCCCTGCTCGGCCTGGAGGCCGCCAAAGGCTATGCCCTGGAGCTGCGCGACCTGGCCCTGGCCGCCCTCGACGGTTTTCCGCCGAGCGCCGACCCGCTGCGCCAACTGGCCCGCTACATCGTCGAGCGACGCAACTGA
Protein Properties
Protein Residues: 295
Protein Molecular Weight: 31.5 kDa
Protein Theoretical pI: 5.06
Hydropathicity (GRAVY score): -0.046
Charge at pH 7 (predicted): -8.43
Protein Sequence: 
>PA4043
MIAAYQARCQARVDAALDALFVAPREELQRLYEAMRYSVMNGGKRVRPLLAYAACEALGGAPQRADAAACAVELIHAYSLVHDDLPAMDDDDLRRGQPTTHRAFDEATAILAADGLQALAFEVLADTRRNPQEHAVCLEMLTRLARAAGSAGMVGGQAIDLGSVGVALDQAALEVMHRHKTGALIEASVRLGALASGRAEPASLAALERYAEAIGLAFQVQDDILDVESDTATLGKTQGKDQAHNKPTYPALLGLEAAKGYALELRDLALAALDGFPPSADPLRQLARYIVERRN
References
External Links:
Resource Link
Genome ID: PA4043
Entrez Gene ID: 879058
NCBI Protein ID: 15599238
General Reference: PaperBLAST - Find papers about PA4043 and its homologs