D-alanyl-D-alanine carboxypeptidase dacC (PA3999)

Identification
Name: D-alanyl-D-alanine carboxypeptidase dacC
Synonyms:
  • DD-carboxypeptidase
  • DD-peptidase
  • Penicillin-binding protein 6
  • PBP-6
Gene Name: dacC
Enzyme Class:
Biological Properties
General Function: Involved in carboxypeptidase activity
Specific Function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
Cellular Location: Cell inner membrane; Peripheral membrane protein.
KEGG Pathways:
KEGG Reactions: Not Available
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
a lipid II+Thumb ? a N-acetylglucosamine--N-acetylmuramyl-(tetrapeptide) pyrophosphoryl-undecaprenol+Thumb
a lipid II + Water ? a N-acetylglucosamine--N-acetylmuramyl-(tetrapeptide) pyrophosphoryl-undecaprenol + D-Alanine
ReactionCard
Complex Reactions:
Thumb+three disacharide linked murein units (pentapeptide crosslinked tetrapeptide (A2pm->D-ala) tetrapeptide corsslinked tetrapeptide (A2pm->D-ala)) (middle of chain) → Thumb+three disacharide linked murein units (tetrapeptide crosslinked tetrapeptide (A2pm->D-ala) & tetrapeptide corsslinked tetrapeptide (A2pm->D-ala)) (middle of chain)
Water + three disacharide linked murein units (pentapeptide crosslinked tetrapeptide (A2pm->D-ala) tetrapeptide corsslinked tetrapeptide (A2pm->D-ala)) (middle of chain) → D-Alanine + three disacharide linked murein units (tetrapeptide crosslinked tetrapeptide (A2pm->D-ala) & tetrapeptide corsslinked tetrapeptide (A2pm->D-ala)) (middle of chain)
ReactionCard
Thumb+two disacharide linked murein units, pentapeptide crosslinked tetrapeptide (A2pm->D-ala) (middle of chain) → Thumb+two disacharide linked murein units, tetrapeptide corsslinked tetrapeptide (A2pm->D-ala) (middle of chain)
Water + two disacharide linked murein units, pentapeptide crosslinked tetrapeptide (A2pm->D-ala) (middle of chain) → D-Alanine + two disacharide linked murein units, tetrapeptide corsslinked tetrapeptide (A2pm->D-ala) (middle of chain)
ReactionCard
Thumb+two linked disacharide pentapeptide and tetrapeptide murein units (uncrosslinked, middle of chain) → Thumb+two linked disacharide tetrapeptide murein units (uncrosslinked, middle of chain)
Water + two linked disacharide pentapeptide and tetrapeptide murein units (uncrosslinked, middle of chain) → D-Alanine + two linked disacharide tetrapeptide murein units (uncrosslinked, middle of chain)
ReactionCard
Thumb+two linked disacharide pentapeptide and tripeptide murein units (uncrosslinked, middle of chain) → Thumb+two linked disacharide tetrapeptide and tripeptide murein units (uncrosslinked, middle of chain)
Water + two linked disacharide pentapeptide and tripeptide murein units (uncrosslinked, middle of chain) → D-Alanine + two linked disacharide tetrapeptide and tripeptide murein units (uncrosslinked, middle of chain)
ReactionCard
Thumb+two linked disacharide pentapeptide murein units (uncrosslinked, middle of chain) → Thumb+two linked disacharide pentapeptide and tetrapeptide murein units (uncrosslinked, middle of chain)
Water + two linked disacharide pentapeptide murein units (uncrosslinked, middle of chain) → D-Alanine + two linked disacharide pentapeptide and tetrapeptide murein units (uncrosslinked, middle of chain)
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000333D-AlanineMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
carboxypeptidase activity
catalytic activity
exopeptidase activity
hydrolase activity
peptidase activity
peptidase activity, acting on L-amino acid peptides
serine-type carboxypeptidase activity
serine-type D-Ala-D-Ala carboxypeptidase activity
Process
macromolecule metabolic process
metabolic process
protein metabolic process
proteolysis
Gene Properties
Locus tag: PA3999
Strand: -
Entrez Gene ID: 878956
Accession: NP_252688.1
GI: 15599194
Sequence start: 4478979
Sequence End: 4480139
Sequence Length: 1160
Gene Sequence: 
>PA3999
ATGAACATCACCACTATCGCGAAACGCTTGTCACTGCTTGTCCTGTTCATCGCCCCTACGGCTGGCTGGGCTGCTGAATCCATGGTTCCGGCGCCGCCGCAACTGGCCGCCAAGTCGTACGTCCTGATGGACGGCGAGAGCGGCCAGGTTCTGGTCGAGAACAACGGCGACCAGCGCCTGCCGCCGGCCAGCCTGACCAAACTGATGACCGCCTACATCGCCACCAAGGAGATCGAGGCCGGCCGCATCGGCGAGAACGACCTGGTCACCGTCAGCGAACATGCCTGGCGCACCGGCGGTTCGCGGATGTTCATCAAGGTCGGCAGCCAGGTATCGGTGAGCGACCTGCTGCATGGCATCATCATCCAGTCCGGCAACGACGCCAGCGTCGCCCTGGCCGAGCATATCGCCGGCAGCGAAGACGCCTTCGCCGACATGATGAACACCACCGCGCAGAAGCTGGGCCTGACCAACTCTCACTTCATGGACGCCACCGGCCTGCCCAACCCGGACCACTATTCCTCCGCCCGCGACATGGCGGTGCTGGCCCGCGCGATCATCTACGGTGAGCCGAGCCACTACGCGATCTACGCGCAGAAGGAATTCCTCTGGAACAACATCAAGCAGCCGAACCGCAACCTGCTGCTGTGGCGCGACAAGACCGTCGACGGCCTGAAGACCGGCCACACCGACGAAGCCGGCTACTGCCTGGTGGCTTCCGCGGTACGCGACGGCCAGCGCATGATCGCCGTGGTGTTCGGCACCAACAGCGAGCAGGCCCGCGCCGCCGAGACCCAGAAGCTGCTGACCTATGGCTTCCGCTTCTTCGAAAGCCGCAACTTCTACAAGAAGGGCACCGAGCTGACCAAGGGCCTGGTCTGGAAGGGTTCCGAGCATGAAGTGAAAGCCGGCCTCGCCGAAGATCTGACCATGACCCTGCCGCGCGGCCAGATGCAGAAGCTGCAGGCCAGCATGGTCCTGGAGCCGCAACTGATGGCGCCGATCCAGCAGGGCCAGGTGATCGGCAAGGTGGAAGTGAAGCTGGACGACAAGGTCATCCGCAGCGCCGACCTGGTCGCCCTCAACGCCGTCGAGGAGGGTGGTTTCTTCCGCCGCCTGTGGGATAGCATCCGCCTGTTCTTCTACGGTTTGTTCAACTGA
Protein Properties
Protein Residues: 386
Protein Molecular Weight: 42.5 kDa
Protein Theoretical pI: 6.73
Hydropathicity (GRAVY score): -0.117
Charge at pH 7 (predicted): -1.1
Protein Sequence: 
>PA3999
MNITTIAKRLSLLVLFIAPTAGWAAESMVPAPPQLAAKSYVLMDGESGQVLVENNGDQRLPPASLTKLMTAYIATKEIEAGRIGENDLVTVSEHAWRTGGSRMFIKVGSQVSVSDLLHGIIIQSGNDASVALAEHIAGSEDAFADMMNTTAQKLGLTNSHFMDATGLPNPDHYSSARDMAVLARAIIYGEPSHYAIYAQKEFLWNNIKQPNRNLLLWRDKTVDGLKTGHTDEAGYCLVASAVRDGQRMIAVVFGTNSEQARAAETQKLLTYGFRFFESRNFYKKGTELTKGLVWKGSEHEVKAGLAEDLTMTLPRGQMQKLQASMVLEPQLMAPIQQGQVIGKVEVKLDDKVIRSADLVALNAVEEGGFFRRLWDSIRLFFYGLFN
References
External Links:
Resource Link
Genome ID: PA3999
Entrez Gene ID: 878956
NCBI Protein ID: 15599194
General Reference: PaperBLAST - Find papers about PA3999 and its homologs