Identification
Name: DNA polymerase III subunit delta
Synonyms: Not Available
Gene Name: holA
Enzyme Class:
Biological Properties
General Function: Involved in DNA binding
Specific Function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions:
Thumb+DNAThumb+DNA
Thumb+DNAThumb+DNA
Thumb+DNAThumb+DNA
Thumb+DNAThumb+DNA
Deoxynucleoside triphosphate+DNAThumb
Deoxynucleoside triphosphate + DNA ↔ Pyrophosphate
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+DNAThumb+DNA
Thumb+DNAThumb+DNA
Thumb+DNAThumb+DNA
Thumb+DNAThumb+DNA
Deoxynucleoside triphosphate+DNA(n)Thumb+DNA(n+1)
Deoxynucleoside triphosphate + DNA(n) → Pyrophosphate + DNA(n+1)
ReactionCard
Deoxynucleoside triphosphate+DNAThumb
Deoxynucleoside triphosphate + DNA ↔ Pyrophosphate
ReactionCard
Complex Reactions:
Deoxynucleoside triphosphate+DNA(n)Thumb+DNA(n+1)
Deoxynucleoside triphosphate + DNA(n) → Pyrophosphate + DNA(n+1)
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000412dATPMetaboCard
PAMDB000219dCTPMetaboCard
PAMDB000389dGTPMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000346Thymidine 5'-triphosphateMetaboCard
GO Classification:
Component
DNA polymerase complex
DNA polymerase III complex
macromolecular complex
protein complex
Function
binding
catalytic activity
DNA binding
DNA polymerase activity
DNA-directed DNA polymerase activity
nucleic acid binding
nucleotidyltransferase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
cellular macromolecule metabolic process
DNA metabolic process
DNA replication
macromolecule metabolic process
metabolic process
Gene Properties
Locus tag: PA3989
Strand: +
Entrez Gene ID: 878936
Accession: NP_252678.1
GI: 15599184
Sequence start: 4470274
Sequence End: 4471311
Sequence Length: 1037
Gene Sequence:
>PA3989
ATGAAGCTGACTCCCGCGCAACTCGCCAAGCACCTCCAGGGCCCCCTGGCGCCCGTCTATGTCGTCAGCGGCGATGAACCGCTGCTCTGCCAGGAAGCCTGCGATGCCATTCGCCAGGCCTGCCGCGAGCGCGACTTCGGCGAGCGCCAGGTATTCAATGCCGAAGCCAACTTCGATTGGGGCTTGCTGCTGGAGGCCGGCGCCAGCCTGTCGCTGTTCGCCGAGAAGCGCCTGATCGAACTGCGCCTGCCCTCCGGCAAGCCCGGCGACAAAGGCGCGGCGATTCTCCAGGAATACCTGCAACGGCCGCCGGAAGACACCGTGCTCCTGCTCGGTCTGCCCAAGCTCGATGGCAGCACGCAGAAGACCAAGTGGGCCAAGGCCCTGATCGATGGCAACGCCGCGCAGTTCATCCAGGTCTGGCCGGTCGACGTCCACCAGTTGCCGCAGTGGATTCGCCAGCGCCTGTCCCAGGCTGGCCTGTCCGCCAGCCCCGAAGCCCTGGAGCTGATCGCCGCGCGCGTGGAAGGCAACCTGCTCGCCGCCGCCCAGGAAATCGAAAAGCTCAAGCTGCTCGCCGAGGGCAACCAGATCGACGCCGCCACCGTACAGGCCGCGGTCGCCGACAGCGCACGCTTCGATGTCTTCGGCCTGATCGACGCTGCCCTTGGCGGTGAAGCGGCCCACGCCCTGCGCATCCTGGAAGGACTGCGCGGCGAAGGCATCGAGCCGCCGGTGATCCTCTGGGGCCTGGCCCGCGAGATCCGCCTGCTGGCTGGCCTGTCCCAGCAATACGGCCAGGGCATCCCGCTGGAGAAAGCCTTCGCCCAGGCGCGTCCGCCGGTCTGGGACAAGCGCCGTCCGCTGCTGACCCGTGCCCTGCAACGCCACTCCAGCAGCCGCTGGAACCAGATGCTGAGGGATGCCCAGTTGATCGACGCGCAGATCAAGGGACAGGCACCCGGCAGCCCCTGGAGCGGTCTCTCGCTTCTCGCCCTGAGCCTCGCCGGCCAGCGCCTCGGCCTGCCGGCAGCCTGA
Protein Properties
Protein Residues: 345
Protein Molecular Weight: 37.4 kDa
Protein Theoretical pI: 6.94
Hydropathicity (GRAVY score): -0.074
Charge at pH 7 (predicted): -0.12
Protein Sequence:
>PA3989
MKLTPAQLAKHLQGPLAPVYVVSGDEPLLCQEACDAIRQACRERDFGERQVFNAEANFDWGLLLEAGASLSLFAEKRLIELRLPSGKPGDKGAAILQEYLQRPPEDTVLLLGLPKLDGSTQKTKWAKALIDGNAAQFIQVWPVDVHQLPQWIRQRLSQAGLSASPEALELIAARVEGNLLAAAQEIEKLKLLAEGNQIDAATVQAAVADSARFDVFGLIDAALGGEAAHALRILEGLRGEGIEPPVILWGLAREIRLLAGLSQQYGQGIPLEKAFAQARPPVWDKRRPLLTRALQRHSSSRWNQMLRDAQLIDAQIKGQAPGSPWSGLSLLALSLAGQRLGLPAA
References
External Links:
Resource Link
Genome ID: PA3989
Entrez Gene ID: 878936
NCBI Protein ID: 15599184
General Reference: PaperBLAST - Find papers about PA3989 and its homologs