2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (PA3627)

Identification
Name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Synonyms:
  • MECDP-synthase
  • MECPS
Gene Name: ispF
Enzyme Class:
Biological Properties
General Function: Involved in 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Specific Function: Converts 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) and CMP. Also converts 4-diphosphocytidyl-2-C-methyl-D- erythritol into 2-C-methyl-D-erythritol 3,4-cyclophosphate and CMP
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb ↔ Thumb+Thumb
2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol ↔ 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate + Cytidine monophosphate
ReactionCard
Thumb ↔ Thumb+Thumb
2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol ↔ 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate + Cytidine monophosphate
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SMPDB Reactions:
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol+Thumb → Cytidine monophosphate+Thumb+Thumb
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + 2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol → Cytidine monophosphate + 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate + Cytidine monophosphate
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Thumb+2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol → Thumb+Cytidine monophosphate+Thumb
2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + 2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol → 2-C-Methyl-D-erythritol 2,4-cyclodiphosphate + Cytidine monophosphate + Cytidine monophosphate
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PseudoCyc/BioCyc Reactions:
Thumb ↔ Thumb+Thumb
2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol ↔ 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate + Cytidine monophosphate
ReactionCard
Complex Reactions:
Thumb → Thumb+Thumb
2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol → 2-C-Methyl-D-erythritol 2,4-cyclodiphosphate + Cytidine monophosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0035022-C-Methyl-D-erythritol 2,4-cyclodiphosphateMetaboCard
PAMDB0006112-C-Methyl-D-erythritol-2,4-cyclodiphosphateMetaboCard
PAMDB0008982-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritolMetaboCard
PAMDB000035Cytidine monophosphateMetaboCard
GO Classification:
Function
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
catalytic activity
lyase activity
phosphorus-oxygen lyase activity
Process
cellular lipid metabolic process
isoprenoid metabolic process
lipid metabolic process
metabolic process
primary metabolic process
terpenoid biosynthetic process
terpenoid metabolic process
Gene Properties
Locus tag: PA3627
Strand: -
Entrez Gene ID: 880484
Accession: NP_252317.1
GI: 15598823
Sequence start: 4062426
Sequence End: 4062899
Sequence Length: 473
Gene Sequence: 
>PA3627
ATGCGAATTGGCCATGGCTACGACGTGCATCGCTTCGGCGAGGGCGACTTCATCACCCTCGGCGGCGTGCGCATTCCCCACAAACATGGGCTGGTCGCCCACTCCGACGGCGACGTGCTGCTGCACGCCTTGTCCGATGCGCTGCTCGGCGCGGCGGCGCTGGGCGACATCGGCAAGCACTTCCCGGACACCGACCCGCGGTTCAAGGGCGCCGACAGTCGCGCGCTGCTGCGACACGTGGTCGCCATCGTCGCCGAGAAGGGCTGGAAGGTCGGCAACGTCGACGCCACGATCGTCGCCCAGGCGCCGAAGATGGCGCCGCACATCGAGACCATGCGCGGGTTGATCGCCGAGGACCTCGGCGTCGCGGTCGACCAGGTCAACGTCAAGGCCACCACTACCGAGCGGCTAGGTTTCACCGGACGCGAAGAGGGCATTGCTGTACATGCGGTCGCTTTGCTGATGGCCCGATGA
Protein Properties
Protein Residues: 157
Protein Molecular Weight: 16.7 kDa
Protein Theoretical pI: 7.1
Hydropathicity (GRAVY score): 0.086
Charge at pH 7 (predicted): 0.39
Protein Sequence: 
>PA3627
MRIGHGYDVHRFGEGDFITLGGVRIPHKHGLVAHSDGDVLLHALSDALLGAAALGDIGKHFPDTDPRFKGADSRALLRHVVAIVAEKGWKVGNVDATIVAQAPKMAPHIETMRGLIAEDLGVAVDQVNVKATTTERLGFTGREEGIAVHAVALLMAR
References
External Links:
Resource Link
Genome ID: PA3627
Entrez Gene ID: 880484
NCBI Protein ID: 15598823
General Reference: PaperBLAST - Find papers about PA3627 and its homologs