Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD (PA3555)

Identification
Name: Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD
Synonyms: Not Available
Gene Name: arnD
Enzyme Class: Not Available
Biological Properties
General Function: Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Specific Function: Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable)
Cellular Location: Cytoplasmic
KEGG Pathways:
  • Amino sugar and nucleotide sugar metabolism pae00520
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Thumb+Thumb → Thumb+Thumb
    Water + Undecaprenyl phosphate-4-amino-4-formyl-L-arabinose → Formic acid + undecaprenyl phosphate-4-amino-4-deoxy-L-arabinose
    ReactionCard
    4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate+Thumb → 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate+Thumb
    4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + Water → 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + Formic acid
    ReactionCard
    Complex Reactions:
    Thumb+Thumb → Thumb+Thumb
    Water + Undecaprenyl phosphate-4-amino-4-formyl-L-arabinose → Formic acid + undecaprenyl phosphate-4-amino-4-deoxy-L-arabinose
    ReactionCard
    4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate+Thumb → 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate+Thumb
    4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + Water → 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + Formic acid
    ReactionCard
    Transports: Not Available
    Metabolites:
    PAMDB IDNameView
    PAMDB000053Formic acidMetaboCard
    PAMDB001760undecaprenyl phosphate-4-amino-4-deoxy-L-arabinoseMetaboCard
    PAMDB001761Undecaprenyl phosphate-4-amino-4-formyl-L-arabinoseMetaboCard
    PAMDB000142WaterMetaboCard
    GO Classification:
    Function
    catalytic activity
    hydrolase activity
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    Process
    carbohydrate metabolic process
    metabolic process
    primary metabolic process
    Gene Properties
    Locus tag: PA3555
    Strand: +
    Entrez Gene ID: 879121
    Accession: NP_252245.1
    GI: 15598751
    Sequence start: 3984006
    Sequence End: 3984893
    Sequence Length: 887
    Gene Sequence: 
    >PA3555
GTGATCCAGGCCGGCCTGCGCATCGACGTCGACACCTTCCGCGGCACCCGCGACGGGGTGCCGCGGCTGCTCGAGCTGCTCGACGAAGCCGGGCTGAAGGCGACCTTCTTCTTCAGCGTCGGCCCGGACAACATGGGCCGCCACCTCTGGCGCCTGGCGCGCCCGGCGTTCTTCTGGAAGATGCTCCGCTCGCGCGCCGCCAGCCTGTATGGCTGGGACATCCTGCTGGCCGGCACCGCCTGGCCGGGCAAGCCGATCGGCCGCGAACTCGGCCCGCTGATGCGGCGGACCCAGGCCGCCGGCCACGAGGTCGGCCTGCACGCCTGGGACCACCATGCCTGGCAGACCCACGCCGGAGTCTGGAGCGTGCAGCAGCTCGGCGAGCAGATCCGCCGCGGCAGCGATTGCCTGGCGGACATCCTCGGCCAGCCGGTGCGTTGTTCCGCCGCCGCCGGCTGGCGCGCCGACGGCCGGGTGGTCGAGGCCAAGCAGCCCTTCGGCTTCCGCTACAACAGCGACTGCCGCGGACGCGGCGCGTTCCGCCCGCGCCTGGCCGACGGCAGCCCTGGCATCCCGCAGGTGCCGGTGAACCTGCCGACCTTCGACGAGGTGGTCGGTCCCGGCCTGCCGCGCGAGGCCTACAACGACTTCATCCTGGAACGCTTCGCCGCTGGCCGCGACAACGTCTACACCATCCACGCCGAGGTCGAGGGGCTGCTCCTCGCCCCGGCGTTCCGCGAACTGCTGCGGCGCGCCGAACGGCGCGGCATCCGCTTCCGACCGTTGGGCGAACTGCTGCCGGACGATCCGCGCAGCCTGCCGCTGGCCGAACTGGTGCGCGGCCGCCTGGCCGGCCGCGAGGGCTGGCTGGGAGTGCGCCAGCCATGA
    Protein Properties
    Protein Residues: 295
    Protein Molecular Weight: 32.9 kDa
    Protein Theoretical pI: 10.39
    Hydropathicity (GRAVY score): -0.285
    Charge at pH 7 (predicted): 9.6
    Protein Sequence: 
    >PA3555
MIQAGLRIDVDTFRGTRDGVPRLLELLDEAGLKATFFFSVGPDNMGRHLWRLARPAFFWKMLRSRAASLYGWDILLAGTAWPGKPIGRELGPLMRRTQAAGHEVGLHAWDHHAWQTHAGVWSVQQLGEQIRRGSDCLADILGQPVRCSAAAGWRADGRVVEAKQPFGFRYNSDCRGRGAFRPRLADGSPGIPQVPVNLPTFDEVVGPGLPREAYNDFILERFAAGRDNVYTIHAEVEGLLLAPAFRELLRRAERRGIRFRPLGELLPDDPRSLPLAELVRGRLAGREGWLGVRQP
    References
    External Links:
    Resource Link
    Genome ID: PA3555
    Entrez Gene ID: 879121
    NCBI Protein ID: 15598751
    General Reference: PaperBLAST - Find papers about PA3555 and its homologs