UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (PA3552)

Identification
Name: UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase
Synonyms:
  • Polymyxin resistance protein pmrH
  • UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase
  • UDP-Ara4O aminotransferase
Gene Name: arnB
Enzyme Class:
Biological Properties
General Function: Involved in transaminase activity
Specific Function: Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides
Cellular Location: Not Available
KEGG Pathways:
  • Amino sugar and nucleotide sugar metabolism pae00520
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
L-Glutamate + UDP-4-Keto-pyranose ↔ alpha-Ketoglutarate + Uridine 5''-diphospho-{beta}-4-deoxy-4-amino-L-arabinose
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
UDP-4-Keto-pyranose + L-Glutamate ↔ Uridine 5''-diphospho-{beta}-4-deoxy-4-amino-L-arabinose + alpha-Ketoglutarate
ReactionCard
SMPDB Reactions:
Thumb+L-Glutamic acid+Thumb → Thumb+Thumb
UDP-β-L-threo-pentapyranos-4-ulose + L-Glutamic acid + L-Glutamate → Oxoglutaric acid + Uridine 5''-diphospho-{beta}-4-deoxy-4-amino-L-arabinose
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Uridine 5''-diphospho-{beta}-4-deoxy-4-amino-L-arabinose + Oxoglutaric acid ↔ UDP-4-Keto-pyranose + L-Glutamate
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0018924-Amino-4-deoxy-L-arabinoseMetaboCard
PAMDB000466alpha-KetoglutarateMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000623Oxoglutaric acidMetaboCard
PAMDB001697UDP-4-Keto-pyranoseMetaboCard
PAMDB003592UDP-beta-L-Threo-pentapyranos-4-uloseMetaboCard
PAMDB006357UDP-β-L-threo-pentapyranos-4-uloseMetaboCard
PAMDB001762Uridine 5''-diphospho-{beta}-4-deoxy-4-amino-L-arabinoseMetaboCard
GO Classification:
Function
binding
catalytic activity
cofactor binding
pyridoxal phosphate binding
Gene Properties
Locus tag: PA3552
Strand: +
Entrez Gene ID: 879143
Accession: NP_252242.1
GI: 15598748
Sequence start: 3979860
Sequence End: 3981008
Sequence Length: 1148
Gene Sequence: 
>PA3552
ATGTCACTGGACTTTCTGCCATTCTCCCGGCCAAGCATCGGCGAGGACGAAATCGCCGCCGTGGAGCAGGTCCTGCGTTCCGGCTGGATCACCACCGGGCCGAAGAACCAGGAGCTCGAACAGCGCTTCGCCGAACGCCTCGGCTGCCGCCACGCGGTGGCGCTATCCTCGGCCACCGGCGCCCTGCACGTCACCCTGCTGGCGCTGGGCATCGGCCCCGGCGACGAAGTGATCACGCCGTCGCTGACCTGGGTCTCCACCGCCAACGTCATCACCCTGCTCGGCGCCACCCCGGTGTTCGTCGACGTCGACCGCGACACCCTGATGTGTTCGGCGCAGGCAGTGGAAGCCGCCATCGGCCCGCGCACCCGCGCCATCGTGCCGGTGCACTACGCCGGCTCCACCCTGGATCTCGAAGGCCTGCGCACGGTCGCCGGGCGCCACGGCATCGCCCTGGTCGAGGACGCCGCCCACGCGGTCGGCAGCGAATACCGCGGGCGCCCGGTAGGCTCCCGCGGCACGGCGATCTTTTCCTTCCACGCGATCAAGAACCTGACCTGCGCCGAAGGCGCGATGTTCGTCAGCGACGACAGTGCCCTCGCCGAACGGGTCCGCCGCCTCAAGTTCCACGGCCTCGGGGTCGATGCCTACGACCGCCTGAGCCATGGACGCAAGCCGCAGGCGGAAGTTATCGAGCCCGGTTTCAAATACAACCTGGCCGACCTCAACGCCGCCCTCGCGCTGGTCCAGCTCAAGCGCCTGGACGCGCTCAACGCGCGCCGCCAGGCCCTCGCCGAACGCTACCTGGAGCGCCTCGCCGGCCTGCCGCTGGCGCCGCTCGGCCTGCCCGCGCACAAGCAGCGCCACGCCTGGCACCTGTTCATCCTGCGCATCGACGCCGAGGTCTGCGGCCTGGGCCGCGACGCCTTCATGGAAGCCCTGAAGGCGCGCGGCATCGGTAGCGGCATCCATTTCATCGCCAGTCACCTGCACCACTACTACCGCCAGCGCCAGCCGCGCCTGAGCCTGCCCAACAGCGAGTGGAACTCGGCCCGCCTGTGCTCCATCCCGCTGTTCCCCGACATGCGCGACGACGACATCGAGCGCGTCGCCCGCGCCATCGAGGAGATCCTGGAGAAACGTCGATGA
Protein Properties
Protein Residues: 382
Protein Molecular Weight: 41.9 kDa
Protein Theoretical pI: 8
Hydropathicity (GRAVY score): -0.061
Charge at pH 7 (predicted): 4.47
Protein Sequence: 
>PA3552
MSLDFLPFSRPSIGEDEIAAVEQVLRSGWITTGPKNQELEQRFAERLGCRHAVALSSATGALHVTLLALGIGPGDEVITPSLTWVSTANVITLLGATPVFVDVDRDTLMCSAQAVEAAIGPRTRAIVPVHYAGSTLDLEGLRTVAGRHGIALVEDAAHAVGSEYRGRPVGSRGTAIFSFHAIKNLTCAEGAMFVSDDSALAERVRRLKFHGLGVDAYDRLSHGRKPQAEVIEPGFKYNLADLNAALALVQLKRLDALNARRQALAERYLERLAGLPLAPLGLPAHKQRHAWHLFILRIDAEVCGLGRDAFMEALKARGIGSGIHFIASHLHHYYRQRQPRLSLPNSEWNSARLCSIPLFPDMRDDDIERVARAIEEILEKRR
References
External Links:
Resource Link
Genome ID: PA3552
Entrez Gene ID: 879143
NCBI Protein ID: 15598748
General Reference: PaperBLAST - Find papers about PA3552 and its homologs