Phosphoserine aminotransferase (PA3167)

Identification
Name: Phosphoserine aminotransferase
Synonyms:
  • Phosphohydroxythreonine aminotransferase
  • PSAT
Gene Name: serC
Enzyme Class:
Biological Properties
General Function: Involved in metabolic process
Specific Function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Is involved in both pyridoxine and serine biosynthesis
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
L-Glutamate + 2-Oxo-3-hydroxy-4-phosphobutanoic acid ↔ alpha-Ketoglutarate + O-Phospho-4-hydroxy-L-threonine
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Thumb+Thumb → Thumb+Thumb
Phosphohydroxypyruvic acid + L-Glutamate → alpha-Ketoglutarate + Phosphoserine
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Thumb+Thumb ↔ Thumb+Thumb
Phosphoserine + alpha-Ketoglutarate ↔ Phosphohydroxypyruvic acid + L-Glutamate
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Thumb+Thumb ↔ Thumb+Thumb
O-Phospho-4-hydroxy-L-threonine + alpha-Ketoglutarate ↔ 2-Oxo-3-hydroxy-4-phosphobutanoic acid + L-Glutamate
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Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Phosphoserine + alpha-Ketoglutarate + O-Phospho-4-hydroxy-L-threonine ↔ Phosphohydroxypyruvic acid + L-Glutamate + 2-Oxo-3-hydroxy-4-phosphobutanoic acid
ReactionCard
SMPDB Reactions:
Thumb+L-Glutamic acid+Thumb → Thumb+Thumb
Phosphohydroxypyruvic acid + L-Glutamic acid + L-Glutamate → Oxoglutaric acid + DL-O-Phosphoserine
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Thumb+L-Glutamic acid+Thumb ↔ A-Ketoglutaric acid oxime+Thumb
2-Oxo-3-hydroxy-4-phosphobutanoic acid + L-Glutamic acid + L-Glutamate ↔ A-Ketoglutaric acid oxime + O-Phospho-4-hydroxy-L-threonine
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Thumb+L-Glutamic acid+Thumb → Thumb+Thumb
Phosphohydroxypyruvic acid + L-Glutamic acid + L-Glutamate → Oxoglutaric acid + DL-O-Phosphoserine
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L-Glutamic acid+Thumb ↔ Thumb
L-Glutamic acid + L-Glutamate ↔ O-Phospho-4-hydroxy-L-threonine
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L-Glutamic acid+Thumb ↔ Thumb+Thumb
L-Glutamic acid + L-Glutamate ↔ Oxoglutaric acid + O-Phospho-4-hydroxy-L-threonine
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L-Glutamic acid+Thumb ↔ Thumb+A-Ketoglutaric acid oxime
L-Glutamic acid + L-Glutamate ↔ O-Phospho-4-hydroxy-L-threonine + A-Ketoglutaric acid oxime
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Thumb+L-Glutamic acid+Thumb ↔ Thumb+Thumb
2-Oxo-3-hydroxy-4-phosphobutanoic acid + L-Glutamic acid + L-Glutamate ↔ O-Phospho-4-hydroxy-L-threonine + Oxoglutaric acid
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
Phosphoserine + Oxoglutaric acid → Phosphohydroxypyruvic acid + L-Glutamate
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Thumb+Thumb → Thumb+Thumb
O-Phospho-4-hydroxy-L-threonine + Oxoglutaric acid → 2-Oxo-3-hydroxy-4-phosphobutanoic acid + L-Glutamate
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0006902-Oxo-3-hydroxy-4-phosphobutanoic acidMetaboCard
PAMDB000466alpha-KetoglutarateMetaboCard
PAMDB006190DL-O-PhosphoserineMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000691O-Phospho-4-hydroxy-L-threonineMetaboCard
PAMDB000623Oxoglutaric acidMetaboCard
PAMDB000229Phosphohydroxypyruvic acidMetaboCard
PAMDB000113PhosphoserineMetaboCard
GO Classification:
Function
binding
catalytic activity
cofactor binding
pyridoxal phosphate binding
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
L-serine biosynthetic process
L-serine metabolic process
metabolic process
serine family amino acid metabolic process
Gene Properties
Locus tag: PA3167
Strand: -
Entrez Gene ID: 882700
Accession: NP_251857.1
GI: 15598363
Sequence start: 3555254
Sequence End: 3556339
Sequence Length: 1085
Gene Sequence: 
>PA3167
GTGAGCAAGCGAGCCTTCAATTTCTGCGCCGGTCCCGCGGCGCTTCCCGACGCAGTTCTGCAACGTGCCCAGGCCGAGCTTCTCGACTGGCGGGGCAAGGGCCTTTCGGTCATGGAAATGAGCCACCGTAGTGATGACTACGTGGCCATCGCCAGCAAGGCCGAGCAGGACCTGCGCGACCTGCTCGACATTCCCTCGGACTACAAGGTGCTGTTCCTGCAGGGCGGCGCCAGCCAGCAGTTCGCCGAGATTCCGCTGAACCTGCTGCCCGAAGATGGCGTCGCCGACTATATCGATACCGGTATCTGGTCGAAGAAGGCCATCGAGGAGGCTCGTCGCTATGGCACCGTGAATGTCGCGGCCAGCGCCAAGGAGTACGACTACTTCGCCATTCCGGGTCAGAACGAGTGGACGCTGACCAAGGACGCGGCCTATGTGCACTACGCCTCCAACGAGACCATCGGCGGCCTCGAGTTCGACTGGATTCCCGAGACCGGCGACGTGCCGCTGGTCACCGACATGTCCTCCGACATCCTCTCGCGCCCGCTCGACGTGTCCCGCTTCGGCCTGATCTATGCCGGGGCGCAGAAGAACATCGGCCCGTCCGGCCTGGTGGTGGTGATCGTTCGCGAAGACCTGCTCGGCCGCGCCCGCAGCGTCTGTCCGACCATGCTCAACTACAAGACCGCCGCGGACAACGGTTCCATGTACAACACCCCGGCGACTTACTCCTGGTACCTGTCCGGCCTGGTCTTCGAATGGCTGAAGGAGCAGGGCGGGGTGACCGCGATGGAGCAGCGCAACCGCGCCAAGAAGGACCTGCTGTACAAGACCATCGATGCCAGCGACTTCTACACCAACCCGATCCAGCCGAGCGCCCGCTCCTGGATGAACGTGCCGTTCCGCCTGGCCGACGAGCGTCTCGACAAGCCGTTCCTGGAAGGCGCCGAGGCGCGCGGGCTGCTCAACCTGAAAGGCCACCGCTCGGTCGGCGGCATGCGCGCTTCCATCTACAACGCCCTTGGCCTGGACGCGGTCGAGGCGCTGGTCGCATACATGGCGGAGTTCGAGAAGGAGCACGGCTGA
Protein Properties
Protein Residues: 361
Protein Molecular Weight: 39.9 kDa
Protein Theoretical pI: 4.71
Hydropathicity (GRAVY score): -0.232
Charge at pH 7 (predicted): -11.09
Protein Sequence: 
>PA3167
MSKRAFNFCAGPAALPDAVLQRAQAELLDWRGKGLSVMEMSHRSDDYVAIASKAEQDLRDLLDIPSDYKVLFLQGGASQQFAEIPLNLLPEDGVADYIDTGIWSKKAIEEARRYGTVNVAASAKEYDYFAIPGQNEWTLTKDAAYVHYASNETIGGLEFDWIPETGDVPLVTDMSSDILSRPLDVSRFGLIYAGAQKNIGPSGLVVVIVREDLLGRARSVCPTMLNYKTAADNGSMYNTPATYSWYLSGLVFEWLKEQGGVTAMEQRNRAKKDLLYKTIDASDFYTNPIQPSARSWMNVPFRLADERLDKPFLEGAEARGLLNLKGHRSVGGMRASIYNALGLDAVEALVAYMAEFEKEHG
References
External Links:
Resource Link
Genome ID: PA3167
Entrez Gene ID: 882700
NCBI Protein ID: 15598363
General Reference: PaperBLAST - Find papers about PA3167 and its homologs