| Identification |
| Name: |
3-isopropylmalate dehydratase large subunit |
| Synonyms: |
- Alpha-IPM isomerase
- IPMI
- Isopropylmalate isomerase
|
| Gene Name: |
leuC |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in 3-isopropylmalate dehydratase activity |
| Specific Function: |
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate |
| Cellular Location: |
Not Available |
| KEGG Pathways: |
- Metabolic pathways pae01100
- Valine, leucine and isoleucine biosynthesis pae00290
|
| KEGG Reactions: |
| | | | |
(R)-2-Methylmalate | ↔ |  | + |  |
| | | | | |
|
| SMPDB Reactions: |
| | | | |
| + | | → | Citramalic acid |
| |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Function |
|---|
| 3-isopropylmalate dehydratase activity | | 4 iron, 4 sulfur cluster binding | | binding | | carbon-oxygen lyase activity | | catalytic activity | | hydro-lyase activity | | iron-sulfur cluster binding | | lyase activity | | metal cluster binding | | Process |
|---|
| branched chain family amino acid metabolic process | | cellular amino acid and derivative metabolic process | | cellular amino acid biosynthetic process | | cellular amino acid metabolic process | | cellular metabolic process | | leucine biosynthetic process | | leucine metabolic process | | metabolic process |
|
| Gene Properties |
| Locus tag: |
PA3121 |
| Strand: |
- |
| Entrez Gene ID: |
882827 |
| Accession: |
NP_251811.1 |
| GI: |
15598317 |
| Sequence start: |
3503292 |
| Sequence End: |
3504716 |
| Sequence Length: |
1424 |
| Gene Sequence: |
>PA3121
ATGGCCGGCAAGACCCTCTACGACAAACTCTGGGACATGCACCTGGTCAAGCAGCGCGACGACGGTTCGGCGCTGATCTACATCGACCGCCATATCCTGCACGAAGTGACCTCGCCGCAGGCCTTCGAGGGTCTTCGCCTGGCCGGGCGCAAGCCGTGGCGGATCGACGCCAACATCGCCACCCCGGACCACAACGTGCCGACCACCCGCACCGAGCGCAAGGGCGGCATCGCCGCCATCGCCGACGAGGTCTCGCGCCTGCAGGTGCAGACCCTCGACGAGAACTGCGACGACTTCGGCATCACCGAATTCAAGATGAACGACGTGCGCCAGGGCATCGTCCATGTGGTCGGTCCGGAGCAGGGCGCGACCCTCCCGGGGATGACCGTGGTCTGCGGCGACTCGCACACTTCCACCCACGGCGCCTTCGGCGCGCTGGCCCACGGCATCGGCACTTCCGAGGTAGAGCATGTGCTGGCGACCCAGTGCCTGGTGGCGAAGAAGATGAAGAACATGCTGGTCAAGGTCGAAGGCAGGCTGCCGGCCGGCGTCACGGCGAAGGATATCGTCCTCGCGGTGATCGGCAGGATCGGCACCGCCGGCGGCAACGGCCACGCCATCGAGTTCGCCGGCAGCGCCATCCGCGACCTGTCCATCGAAGGGCGGATGACCATCTGCAACATGTCGATCGAGGCGGGCGCCCGCGTCGGCCTGGTCGCCGTCGACCAGAAGACCATCGACTACGTGAAGGGCCGGCCCTTCGCGCCGAGCGCCGAGCAATGGGACCAGGCCGTCGCCTGCTGGCAGGGGCTGGTGTCGGACGCCGATGCCCGCTTCGATACCGTGGTCGAGCTGGACGCCGCGCAGATCAAGCCGCAGGTCAGCTGGGGCACGTCGCCGGAAATGGTCCTGGCCGTGGACCAGAACGTGCCGGACCCGGCCCGCGAGAGCGACCCGATCAAGCGCGGTTCGATCGAGCGCGCCTTGAAGTACATGGGCCTGCGGCCGAACCAGGCGATCACCGACATCCAGCTGGACCGGGTATTCATCGGTTCCTGCACCAACTCGCGGATCGAGGACCTGCGCGCTGCCGCCGAAGTTGCCAGGGGCCGCAAGGTCGCCGCGACCATCAAGCAGGCGCTGGTGGTGCCGGGTTCCGGGTTGGTCAAGGAGCAGGCCGAGAAGGAAGGCCTGGACCGGATCTTCATCGAGGCCGGCTTCGAATGGCGCGAGCCGGGCTGTTCCATGTGCCTGGCGATGAACCCGGACCGGCTGGAGAGCGGCGAACACTGCGCCTCGACCTCCAACCGCAACTTCGAGGGCCGTCAGGGCGCCGGTGGCCGTACCCACCTGGTCAGCCCGGCGATGGCCGCCGCCGCGGCCGTCAACGGCCGCTTCATCGATGTCCGCGAATTGCTCGCCTGA |
| Protein Properties |
| Protein Residues: |
474 |
| Protein Molecular Weight: |
51 kDa |
| Protein Theoretical pI: |
6.25 |
| Hydropathicity (GRAVY score): |
-0.166 |
| Charge at pH 7 (predicted): |
-5.36 |
| Protein Sequence: |
>PA3121
MAGKTLYDKLWDMHLVKQRDDGSALIYIDRHILHEVTSPQAFEGLRLAGRKPWRIDANIATPDHNVPTTRTERKGGIAAIADEVSRLQVQTLDENCDDFGITEFKMNDVRQGIVHVVGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVAKKMKNMLVKVEGRLPAGVTAKDIVLAVIGRIGTAGGNGHAIEFAGSAIRDLSIEGRMTICNMSIEAGARVGLVAVDQKTIDYVKGRPFAPSAEQWDQAVACWQGLVSDADARFDTVVELDAAQIKPQVSWGTSPEMVLAVDQNVPDPARESDPIKRGSIERALKYMGLRPNQAITDIQLDRVFIGSCTNSRIEDLRAAAEVARGRKVAATIKQALVVPGSGLVKEQAEKEGLDRIFIEAGFEWREPGCSMCLAMNPDRLESGEHCASTSNRNFEGRQGAGGRTHLVSPAMAAAAAVNGRFIDVRELLA |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA3121 and its homologs
|
