Thymidylate kinase (PA2962)

Identification
Name: Thymidylate kinase
Synonyms:
  • Thymidine monophosphate kinase
  • dTMP kinase
  • TMPK
Gene Name: tmk
Enzyme Class:
Biological Properties
General Function: Involved in thymidylate kinase activity
Specific Function: Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + 5-Thymidylic acid ↔ ADP + dTDP
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + 5-Thymidylic acid ↔ ADP + dTDP
ReactionCard
Thumb+Thumb ↔ Thumb+dUDP
Adenosine triphosphate + dUMP ↔ ADP + dUDP
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + 5-Thymidylic acid ↔ ADP + dTDP
ReactionCard
Thumb+Thumb → Thumb+Thumb
5-Thymidylic acid + Adenosine triphosphate → dTDP + ADP
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Adenosine triphosphate + 5-Thymidylic acid → ADP + dTDP
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0003035-Thymidylic acidMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000320dTDPMetaboCard
PAMDB000221dUDPMetaboCard
PAMDB000375dUMPMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
nucleoside binding
phosphotransferase activity, phosphate group as acceptor
purine nucleoside binding
thymidylate kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
cellular nitrogen compound metabolic process
dTDP biosynthetic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
pyrimidine deoxyribonucleoside diphosphate biosynthetic process
pyrimidine nucleoside diphosphate biosynthetic process
pyrimidine nucleotide biosynthetic process
pyrimidine nucleotide metabolic process
Gene Properties
Locus tag: PA2962
Strand: -
Entrez Gene ID: 878730
Accession: NP_251652.1
GI: 15598158
Sequence start: 3321043
Sequence End: 3321675
Sequence Length: 632
Gene Sequence: 
>PA2962
GTGACCGGCCTGTTCGTCACCCTGGAGGGCCCGGAAGGGGCCGGCAAGAGCACCAACCGCGACTACCTGGCCGAGCGCCTGCGCGAGCGCGGCATCGAGGTGCAGTTGACCCGCGAGCCTGGCGGCACGCCTCTCGCCGAGCGCATCCGTGAACTGCTGCTGGCGCCCAGCGACGAGCCGATGGCCGCCGATACCGAGCTGTTGCTGATGTTCGCCGCGCGGGCCCAGCATCTCGCCGGGGTCATCCGCCCGGCGCTGGCGCGCGGGGCCGTGGTGCTCTGCGATCGCTTTACCGATGCCACCTATGCCTACCAGGGCGGCGGGCGCGGTTTGCCGGAGGCGCGCATCGCCGCGCTGGAAAGCTTCGTCCAGGGCGACCTGCGGCCCGACCTCACGCTGGTCTTCGACCTGCCGGTGGAAATCGGCCTGGCGCGGGCGGCGGCGCGTGGCCGGCTCGACCGTTTCGAGCAGGAGGACCGACGCTTCTTCGAGGCCGTGCGTCAGACCTACCTGCAGCGCGCCGCGCAGGCCCCGGAGCGTTACCAGGTGCTCGATGCCGGGTTGCCGCTGGCCGAGGTGCAGGCTGGCCTGGATCGGCTGCTGCCGAATCTGCTGGAGCGTCTGAATGGCTGA
Protein Properties
Protein Residues: 210
Protein Molecular Weight: 23.1 kDa
Protein Theoretical pI: 4.86
Hydropathicity (GRAVY score): -0.177
Charge at pH 7 (predicted): -4.79
Protein Sequence: 
>PA2962
MTGLFVTLEGPEGAGKSTNRDYLAERLRERGIEVQLTREPGGTPLAERIRELLLAPSDEPMAADTELLLMFAARAQHLAGVIRPALARGAVVLCDRFTDATYAYQGGGRGLPEARIAALESFVQGDLRPDLTLVFDLPVEIGLARAAARGRLDRFEQEDRRFFEAVRQTYLQRAAQAPERYQVLDAGLPLAEVQAGLDRLLPNLLERLNG
References
External Links:
Resource Link
Genome ID: PA2962
Entrez Gene ID: 878730
NCBI Protein ID: 15598158
General Reference: PaperBLAST - Find papers about PA2962 and its homologs