Threonyl-tRNA synthetase (PA2744)

Identification
Name: Threonyl-tRNA synthetase
Synonyms:
  • Threonine--tRNA ligase
  • ThrRS
Gene Name: thrS
Enzyme Class:
Biological Properties
General Function: Involved in nucleotide binding
Specific Function: ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+tRNA(Thr)+tRNA(Thr) ↔ Thumb+Thumb+L-Threonyl-tRNA(Thr)+L-Threonyl-tRNA(Thr)
Adenosine triphosphate + L-Threonine + tRNA(Thr) + tRNA(Thr) ↔ Adenosine monophosphate + Pyrophosphate + L-Threonyl-tRNA(Thr) + L-Threonyl-tRNA(Thr)
ReactionCard
Thumb+Thumb+tRNA(Thr) ↔ Thumb+Thumb+L-Threonyl-tRNA(Thr)
Adenosine triphosphate + L-Threonine + tRNA(Thr) ↔ Adenosine monophosphate + Pyrophosphate + L-Threonyl-tRNA(Thr)
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+tRNA(Thr)+tRNA(Thr) ↔ Thumb+Thumb+L-Threonyl-tRNA(Thr)+L-Threonyl-tRNA(Thr)
Adenosine triphosphate + L-Threonine + tRNA(Thr) + tRNA(Thr) ↔ Adenosine monophosphate + Pyrophosphate + L-Threonyl-tRNA(Thr) + L-Threonyl-tRNA(Thr)
ReactionCard
Thumb+Thumb+tRNA(Thr) ↔ Thumb+Thumb+L-Threonyl-tRNA(Thr)
Adenosine triphosphate + L-Threonine + tRNA(Thr) ↔ Adenosine monophosphate + Pyrophosphate + L-Threonyl-tRNA(Thr)
ReactionCard
Thumb+Thumb+tRNA(Thr) → Thumb+Thumb+L-threonyl-tRNA(Thr)
Adenosine triphosphate + L-Threonine + tRNA(Thr) → Adenosine monophosphate + Pyrophosphate + L-threonyl-tRNA(Thr)
ReactionCard
Thumb
a tRNAthr + L-threonine + ATP + H+ → an L-threonyl-[tRNAthr] + AMP + diphosphate
ReactionCard
Complex Reactions:
Thumb+Thumb+tRNA(Thr) → Thumb+Thumb+L-threonyl-tRNA(Thr)
Adenosine triphosphate + L-Threonine + tRNA(Thr) → Adenosine monophosphate + Pyrophosphate + L-threonyl-tRNA(Thr)
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000068L-ThreonineMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
aminoacyl-tRNA ligase activity
ATP binding
binding
catalytic activity
ligase activity
ligase activity, forming aminoacyl-tRNA and related compounds
ligase activity, forming carbon-oxygen bonds
nucleoside binding
nucleotide binding
purine nucleoside binding
threonine-tRNA ligase activity
Process
biosynthetic process
cellular macromolecule biosynthetic process
cellular macromolecule metabolic process
macromolecule biosynthetic process
macromolecule metabolic process
metabolic process
ncRNA metabolic process
RNA metabolic process
threonyl-tRNA aminoacylation
translation
tRNA aminoacylation
tRNA aminoacylation for protein translation
tRNA metabolic process
Gene Properties
Locus tag: PA2744
Strand: -
Entrez Gene ID: 882972
Accession: NP_251434.1
GI: 15597940
Sequence start: 3104830
Sequence End: 3106752
Sequence Length: 1922
Gene Sequence: 
>PA2744
ATGCCCATCATTACTCTTCCCGACGGCAGTCAACGTTCCTTCGATCACCCGGTCTCCGTGGCCGAGGTGGCCCAATCCATCGGCGCGGGCCTGGCCAAGGCGACCCTCGCCGGCAAGGTCGACGGCCGCCTGGTCGACGCCTGCGACACCATCGATCGCGACGCGACCCTGCAGATCATCACGCCCAAGGACGAGGAAGGACTGGAGATCATCCGCCACTCCTGCGCCCACCTGGTCGGCCATGCGGTCAAGCAGCTCTATCCGACCGCGAAGATGGTCATCGGCCCGGTGATCGAGGAAGGCTTCTACTACGACATTTTCTTCGAGCGCCCCTTCACCCCCGAGGACATGGCGGCGATCCAGCAGCGCATGCGCGAGCTGATCGACAAGGACTACGACGTGATCAAGAAGATGACCCCGCGCGCCGAGGTCATCGAGCTGTTCAAGTCCCGTGGCGAAGACTACAAGCTGCGCCTGATCGACGACATGCCGGACGAGAAGGCCATGGGCCTGTACTTCCATGAGGAGTACGTGGACATGTGCCGCGGCCCGCATGTGCCGAACACCCGCTTCCTCAAGGCGTTCCAACTGACCAAGATTTCCGGCGCCTACTGGCGCGGCGACTCGAAGAACGAGCAGTTGCAACGCATCTACGGCACCGCCTGGGCCGACAAGAAGCAACTGGCGGCCTACATCCAGCGCATCGAAGAGGCCGAGAAGCGCGACCATCGCCGCATCGGCAAGCAGCTCGACCTGTTCCACCTGCAGGAAGAAGCGCCGGGCATGGTGTTCTGGCACCCGAATGGCTGGAGCGTCTACCAGGTGCTCGAGCAGTACATGCGCAAGGTCCAGCGCGACCATGGCTATGTCGAAGTGCGTACCCCGCAGGTGGTCGACCGCATCCTCTGGGAGCGTTCGGGCCACTGGTCGAACTACGCCGAGAACATGTTCACCACCTCCTCGGAAAGTCGCGACTACGCGGTCAAGCCGATGAACTGCCCGTGCCACGTGCAGATCTTCAACCAGGGCCTGAAGTCCTACCGCGACCTGCCGCTGCGCCTCGCCGAGTTCGGCGCCTGCCACCGCAACGAGCCGTCCGGCGCGCTGCACGGGATCATGCGCGTACGCGGCTTTACCCAGGACGACGCGCATATCTTCTGCACCGAAGAGCAGGTGAAGAAGGAAGCGGCCGATTTCATCAAGCTGACCTTGCAGGTCTACCGCGACTTCGGTTTCACCGACATCGCCATGAAGCTGTCGACCCGTCCGGCCAAGCGCGTCGGTTCCGACGAGCTGTGGGATCGCGCCGAAGGCGCGCTGGCCGATGCGCTGAACGAATCCGGCCTGGCCTGGGAATACCAGCCGGGCGAGGGCGCGTTCTACGGGCCGAAGATCGAGTTCACCCTGAAGGACTGCCTCGGCCGTAACTGGCAGTGCGGCACCCTGCAGTACGACCCGAACCTGCCGGAGCGCCTGGACGCCAGCTATATCGCCGAGGACAACAACCGTAAGCGTCCGGTGATGCTGCACCGTGCGATCCTCGGGTCCTTCGAGCGCTTCATCGGCATGCTCATCGAGCACTACGCCGGAGCCTTCCCGGCCTGGCTGGCGCCGACCCAGGCAGTGGTGATGAACATCACCGACAAGCAGGCCGATTTCGCCGCCGAGGTGGTGCGGATCCTCGGGGAAAGCGGATTCCGTGCCAAGTCCGACTTGAGAAACGAGAAGATCGGCTTTAAAATCCGCGAGCATACTTTGCTCAAGGTTCCCTATCTCTTGGTTATTGGAGATCGGGAAGTTGAATCGAAGGCCGTCGCGGTGCGTACGCGCGAAGGGGAAGACCTGGGCTCCATGCCCGTCACCCAGTTCGCTGAGCTGTTGGCACAGGCGGTTTCCCGGCGTGGTCGCCAAGACTCGGAGTAA
Protein Properties
Protein Residues: 640
Protein Molecular Weight: 73.1 kDa
Protein Theoretical pI: 6.34
Hydropathicity (GRAVY score): -0.443
Charge at pH 7 (predicted): -6.9
Protein Sequence: 
>PA2744
MPIITLPDGSQRSFDHPVSVAEVAQSIGAGLAKATLAGKVDGRLVDACDTIDRDATLQIITPKDEEGLEIIRHSCAHLVGHAVKQLYPTAKMVIGPVIEEGFYYDIFFERPFTPEDMAAIQQRMRELIDKDYDVIKKMTPRAEVIELFKSRGEDYKLRLIDDMPDEKAMGLYFHEEYVDMCRGPHVPNTRFLKAFQLTKISGAYWRGDSKNEQLQRIYGTAWADKKQLAAYIQRIEEAEKRDHRRIGKQLDLFHLQEEAPGMVFWHPNGWSVYQVLEQYMRKVQRDHGYVEVRTPQVVDRILWERSGHWSNYAENMFTTSSESRDYAVKPMNCPCHVQIFNQGLKSYRDLPLRLAEFGACHRNEPSGALHGIMRVRGFTQDDAHIFCTEEQVKKEAADFIKLTLQVYRDFGFTDIAMKLSTRPAKRVGSDELWDRAEGALADALNESGLAWEYQPGEGAFYGPKIEFTLKDCLGRNWQCGTLQYDPNLPERLDASYIAEDNNRKRPVMLHRAILGSFERFIGMLIEHYAGAFPAWLAPTQAVVMNITDKQADFAAEVVRILGESGFRAKSDLRNEKIGFKIREHTLLKVPYLLVIGDREVESKAVAVRTREGEDLGSMPVTQFAELLAQAVSRRGRQDSE
References
External Links:
Resource Link
Genome ID: PA2744
Entrez Gene ID: 882972
NCBI Protein ID: 15597940
General Reference: PaperBLAST - Find papers about PA2744 and its homologs