PqsH (PA2587)

Identification
Name: PqsH
Synonyms:
  • 2-heptyl-3-hydroxy-4(1H)-quinolone synthase
Gene Name: pqsH
Enzyme Class:

EC 1.14.13.182

Biological Properties
General Function: secondary metabolite biosynthetic process, quorum sensing, aromatic compound catabolic process, cofactor biosynthetic process, metabolic process
Specific Function: monooxygenase activity, oxidoreductase activity
Cellular Location: Cytoplasmic
KEGG Pathways:
  • 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis PWY-6660
    KEGG Reactions:
    Thumb + Thumb Thumb → Thumb + thumb + thumb

    HHQ + NADH + O2 → PQS + H2O + NAD+
    ReactionCard
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Thumb
    2-heptyl-4(1H)-quinolone + NADH + oxygen + H+ → 2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
    ReactionCard
    Complex Reactions: Not Available
    Transports: Not Available
    Metabolites:
    PAMDB ID Name View
    PAMDB100092 2-aminobenzoylacetyl-CoA MetaboCard
    PAMDB000398 NADH MetaboCard
    PAMDB000624 O2 MetaboCard
    PAMDB100072 HHQ MetaboCard
    PAMDB100069 PQS MetaboCard
    PAMDB000142 H2O MetaboCard
    PAMDB000197 NAD+ MetaboCard
    GO Classification:
    Function
    monooxygenase activity
    oxidoreductase activity
    Process
    secondary metabolite biosynthetic process
    quorum sensing
    aromatic compound catabolic process
    cofactor biosynthetic process
    metabolic process
    Gene Properties
    Locus tag: PA2587
    Strand: -
    Entrez Gene ID: 879540
    Accession: NP_251277.1
    GI: 15597783
    Sequence start: 2926773
    Sequence End: 2927921
    Sequence Length: 1149
    Gene Sequence: 
    >PA2587
ATGACCGTTCTTATCCAGGGGGCCGGGATCGCCGGCCTGGCGCTGGCGCGCGAATTCACCAAGGCAGGCATCGACTGGCTGCTGGTCGAGCGGGCCAGCG AGATCAGGCCCATCGGTACCGGCATCACCCTGGCGAGCAATGCGTTGACGGCGTTGTCCAGCACCCTGGATCTCGACCGGCTGTTCCGCCGTGGCATGCC GTTGGCCGGCATCAACGTATACGCCCACGACGGTTCGATGCTGATGTCGATGCCTTCCAGTCTGGGTGGGAATTCCCGCGGCGGCCTGGCGTTGCAGCGC CACGAACTGCATGCGGCGCTACTGGAGGGGCTGGATGAGTCGCGCATTCGGGTCGGGGTCTCCATCGTGCAGATCCTCGACGGACTCGACCACGAACGCG TGACCCTGAGCGACGGCACTGTCCACGACTGTTCGCTGGTGGTCGGTGCGGATGGCATTCGTTCGAGCGTGCGACGTTATGTCTGGCCGGAGGCGACCTT GCGTCATTCCGGCGAAACCTGCTGGCGCCTGGTCGTTCCCCATCGGCTGGAGGACGCCGAGCTGGCGGGAGAGGTCTGGGGGCACGGCAAGCGCCTCGGC TTCATCCAGATCAGCCCGCGCGAGATGTATGTCTACGCGACCCTGAAGGTGCGCCGGGAGGAGCCCGAGGACGAGGAGGGCTTCGTAACCCCGCAACGGC TGGCCGCCCACTACGCGGACTTCGACGGCATCGGCGCGAGCATCGCCCGGCTCATACCGAGCGCCACCACGCTGGTGCACAACGACCTCGAGGAGTTGGC CGGCGCCTCCTGGTGCCGCGGACGGGTAGTGCTGATCGGTGACGCCGCACACGCCATGACGCCGAACCTGGGGCAGGGCGCGGCCATGGCCCTGGAGGAC GCCTTCCTGCTGGCGCGCCTGTGGTGCCTGGCGCCGCGCGCCGAGACGCTGATCCTGTTCCAGCAGCAACGCGAGGCGCGGATCGAGTTCATCAGGAAGC AATCCTGGATCGTCGGCCGCCTTGGTCAGTGGGAATCGCCCTGGAGCGTCTGGCTGAGGAATACCCTCGTTCGCCTGGTGCCGAATGCCAGTCGCAGGCG CCTCCACCAGCGTCTTTTCACCGGTGTCGGTGAGATGGCCGCACAGTAG
    Protein Properties
    Protein Residues: 382
    Protein Molecular Weight: 42.1 kDa
    Protein Theoretical pI: 7.15
    Hydropathicity (GRAVY score): -0.01
    Charge at pH 7 (predicted): 0.78
    Protein Sequence: 
    >PA2587
MTVLIQGAGIAGLALAREFTKAGIDWLLVERASEIRPIGTGITLASNALTALSSTLDLDRLFRRGMPLAGINVYAHDGSMLMSMPSSLGGNSRGGLALQR HELHAALLEGLDESRIRVGVSIVQILDGLDHERVTLSDGTVHDCSLVVGADGIRSSVRRYVWPEATLRHSGETCWRLVVPHRLEDAELAGEVWGHGKRLG FIQISPREMYVYATLKVRREEPEDEEGFVTPQRLAAHYADFDGIGASIARLIPSATTLVHNDLEELAGASWCRGRVVLIGDAAHAMTPNLGQGAAMALED AFLLARLWCLAPRAETLILFQQQREARIEFIRKQSWIVGRLGQWESPWSVWLRNTLVRLVPNASRRRLHQRLFTGVGEMAAQ
    References
    External Links:
    Resource Link
    Genome ID: PA2587
    Entrez Gene ID: 879540
    NCBI Protein ID: 15597783
    General Reference: PaperBLAST - Find papers about PA2587 and its homologs