Sensor protein phoQ (PA1180)

Identification
Name: Sensor protein phoQ
Synonyms: Not Available
Gene Name: phoQ
Enzyme Class:
Biological Properties
General Function: Involved in ATP binding
Specific Function: Member of the two-component regulatory system phoQ/phoP involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to phoP, which results in the expression of phoP-activated genes (PAG) and repression of phoP-repressed genes (PRG). In presence of high periplasmic Mg(2+) concentrations, acts as a protein phosphatase that dephosphorylates phospho-phoP, which results in the repression of phoP-activated genes and may lead to expression of some phoP- repressed genes. Mediates magnesium influx to the cytosol by activation of mgtA. Promotes expression of the two- component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes
Cellular Location: Cell inner membrane; Multi-pass membrane protein
KEGG Pathways:
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Thumb+protein L-histidine → Thumb+protein N-phospho-L-histidine
    Adenosine triphosphate + protein L-histidine → ADP + protein N-phospho-L-histidine
    ReactionCard
    Complex Reactions:
    Thumb+protein L-histidine → Thumb+protein N-phospho-L-histidine
    Adenosine triphosphate + protein L-histidine → ADP + protein N-phospho-L-histidine
    ReactionCard
    Transports: Not Available
    Metabolites:
    PAMDB IDNameView
    PAMDB000148Adenosine triphosphateMetaboCard
    PAMDB000345ADPMetaboCard
    GO Classification:
    Component
    cell part
    integral to membrane
    intrinsic to membrane
    membrane
    membrane part
    Function
    adenyl nucleotide binding
    adenyl ribonucleotide binding
    ATP binding
    binding
    catalytic activity
    cation binding
    ion binding
    kinase activity
    metal ion binding
    molecular transducer activity
    nucleoside binding
    protein histidine kinase activity
    protein kinase activity
    purine nucleoside binding
    signal transducer activity
    transferase activity
    transferase activity, transferring phosphorus-containing groups
    two-component sensor activity
    Process
    biological regulation
    cellular metabolic process
    metabolic process
    peptidyl-histidine phosphorylation
    phosphate metabolic process
    phosphorus metabolic process
    phosphorylation
    protein amino acid phosphorylation
    regulation of biological process
    regulation of cellular process
    signal transduction
    signal transmission
    signaling process
    two-component signal transduction system (phosphorelay)
    Gene Properties
    Locus tag: PA1180
    Strand: +
    Entrez Gene ID: 879187
    Accession: NP_249871.1
    GI: 15596377
    Sequence start: 1278362
    Sequence End: 1279708
    Sequence Length: 1346
    Gene Sequence: 
    >PA1180
GTGATCCGTTCCCTGCGCATCCGTCTGATGCTCGGCGCCGCCGCCCTGGCGGTGCTGTTCATGCTGGCGCTGCTGCCGGCCCTGCAGCGGGCCTTCGGCATCGCCCTGGAGAACACCATCGAGCAGCGCCTGGCCGCCGACGTGGCGACCCTGGTCTCGGCGGCGCGGGTGGAGAAGGGCCGCCTGGTGATGCCCGAGCACCTGCCGGTGGAGGAGTTCAACCTGCCGGAGGCCAAGGTCCTCGGCTATATCTACGACCAGAATGGCGATCTGCTCTGGCGCTCCACCTCGGCGGCCGACGAGTCGATCAACTACACGCCGCGCTACGACGGCCGCGGCAACGAATTCCACACCACCCGCGATGCGAAGGGCGAGGAGTTCTTCGTGTTCGACGTCGAGATCGACCTGCTGCGCGGCAAGCAGGCGGCCTACAGCATCGTCACCATGCAATCGGTCAGCGAGTTCGAGAGCCTGCTCAAGGGGTTCCGCGAGCAGCTCTACCTGTGGCTCGGCGGCGCCCTGCTGGTCTTGCTCGGGCTGCTCTGGCTGGGTCTGACCTGGGGCTTCCGGGCGATGCGCGGGTTGAGTTCCGAGCTGGACCAGATCGAATCCGGCGAGCGCGAGAGCCTGAGCGAGGAGCATCCGCGCGAGCTGCTGCGCCTGACCCACTCGCTTAACCGCCTGTTGCGCAGCGAGCACAAACAGCGCGAGCGCTACCGCCACTCCCTCGGCGACCTGGCGCACAGTCTGAAGACGCCGCTGGCGGTCTTGCAGGGGGTCGGCGACCAGCTCGCCGAGGAGCCCGGCAACCGCGAGCAGGTGCGGGTGCTACAGGGCCAGATCGAGCGCATGAGCCAGCAGATAGGCTATCAGTTGCAGCGCGCCAGCCTGCGCAAGAGCGGCCTGGTACGCCATCGCGAGCAACTGGCGCCGCTGGTGGAGACCCTGTGCGACGCGCTGGACAAGGTCTATCGCGACAAGCGGGTAAGCCTGCAGCGGGACTTCTCGCCGTCCTTCAGCGTGCCGGTGGAGCGCGGCGCGCTGCTGGAACTGCTCGGCAACCTGCTGGAGAACGCCTATCGCCTGTGCCTGGGCCGGGTCCGCGTGGGCGCCCGGCTGGGGCCGGGTTACTCGGAGCTGTGGGTCGAGGACGACGGTCCCGGAGTGCCTGCCGAACAGCGCGCACGAATCATCCGCCGCGGCGAGCGCGCCGATACCCAGCACCCGGGGCAGGGCATCGGCCTGGCCGTGGCGCTGGACATCATCGAGAGCTACGACGGCGAACTGAGCCTGGACGATTCCGAGCTGGGCGGCGCCTGCTTCCGCATACGTTTCGCTACAGTCTGA
    Protein Properties
    Protein Residues: 448
    Protein Molecular Weight: 50.2 kDa
    Protein Theoretical pI: 6.09
    Hydropathicity (GRAVY score): -0.204
    Charge at pH 7 (predicted): -4.9
    Protein Sequence: 
    >PA1180
MIRSLRIRLMLGAAALAVLFMLALLPALQRAFGIALENTIEQRLAADVATLVSAARVEKGRLVMPEHLPVEEFNLPEAKVLGYIYDQNGDLLWRSTSAADESINYTPRYDGRGNEFHTTRDAKGEEFFVFDVEIDLLRGKQAAYSIVTMQSVSEFESLLKGFREQLYLWLGGALLVLLGLLWLGLTWGFRAMRGLSSELDQIESGERESLSEEHPRELLRLTHSLNRLLRSEHKQRERYRHSLGDLAHSLKTPLAVLQGVGDQLAEEPGNREQVRVLQGQIERMSQQIGYQLQRASLRKSGLVRHREQLAPLVETLCDALDKVYRDKRVSLQRDFSPSFSVPVERGALLELLGNLLENAYRLCLGRVRVGARLGPGYSELWVEDDGPGVPAEQRARIIRRGERADTQHPGQGIGLAVALDIIESYDGELSLDDSELGGACFRIRFATV
    References
    External Links:
    Resource Link
    Genome ID: PA1180
    Entrez Gene ID: 879187
    NCBI Protein ID: 15596377
    General Reference: PaperBLAST - Find papers about PA1180 and its homologs