Identification
Name: Ribosomal RNA small subunit methyltransferase A
Synonyms:
  • 16S rRNA dimethyladenosine transferase
  • 16S rRNA dimethylase
  • High level kasugamycin resistance protein ksgA
  • Kasugamycin dimethyltransferase
  • S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Gene Name: rsmA
Enzyme Class:
Biological Properties
General Function: Translation, ribosomal structure and biogenesis
Specific Function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Has also a DNA glycosylase/AP lyase activity that removes C mispaired with oxidized T from DNA, and may play a role in protection of DNA against oxidative stress
Cellular Location: Cytoplasm (Potential)
KEGG Pathways:
KEGG Reactions: Not Available
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000205S-AdenosylhomocysteineMetaboCard
PAMDB000289S-AdenosylmethionineMetaboCard
GO Classification:
Function
catalytic activity
methyltransferase activity
N-methyltransferase activity
RNA methyltransferase activity
rRNA (adenine) methyltransferase activity
rRNA (adenine-N6,N6-)-dimethyltransferase activity
rRNA methyltransferase activity
transferase activity
transferase activity, transferring one-carbon groups
Process
cellular macromolecule metabolic process
macromolecule metabolic process
metabolic process
ncRNA metabolic process
RNA metabolic process
rRNA metabolic process
rRNA modification
rRNA processing
Gene Properties
Locus tag: PA0905
Strand: +
Entrez Gene ID: 878352
Accession: NP_249596.1
GI: 15596102
Sequence start: 991013
Sequence End: 991198
Sequence Length: 185
Gene Sequence:
>PA0905
ATGCTGATTCTGACTCGTCGGGTCGGAGAGACCCTGATGGTAGGTGACGACGTCACCGTGACGGTACTGGGTGTCAAAGGGAACCAGGTGCGCATCGGCGTCAACGCGCCGAAGGAAGTCGCCGTACACCGGGAGGAAATTTACCAGCGCATCCAGAAAGAGAAAGATCAAGAGCCAAACCATTAA
Protein Properties
Protein Residues: 61
Protein Molecular Weight: 6.9 kDa
Protein Theoretical pI: 7.7
Hydropathicity (GRAVY score): -0.446
Charge at pH 7 (predicted): 0.46
Protein Sequence:
>PA0905
MLILTRRVGETLMVGDDVTVTVLGVKGNQVRIGVNAPKEVAVHREEIYQRIQKEKDQEPNH
References
External Links:
Resource Link
Genome ID: PA0905
Entrez Gene ID: 878352
NCBI Protein ID: 15596102
General Reference: PaperBLAST - Find papers about PA0905 and its homologs