Acetylornithine/succinyldiaminopimelate aminotransferase (PA0895)

Identification
Name: Acetylornithine/succinyldiaminopimelate aminotransferase
Synonyms:
  • ACOAT
  • DapATase
  • Succinyldiaminopimelate transferase
Gene Name: argD
Enzyme Class:
Biological Properties
General Function: Involved in transaminase activity
Specific Function: Involved in both the arginine and lysine biosynthetic pathways
Cellular Location: Cytoplasm (Probable)
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
N-Acetylornithine + alpha-Ketoglutarate ↔ N-Acetyl-L-glutamate 5-semialdehyde + L-Glutamate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
alpha-Ketoglutarate + N-Succinyl-L,L-2,6-diaminopimelate ↔ L-Glutamate + N-Succinyl-2-amino-6-ketopimelate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
N-Acetylornithine + alpha-Ketoglutarate ↔ N-Acetyl-L-glutamate 5-semialdehyde + L-Glutamate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
N-Succinyl-L,L-2,6-diaminopimelate + alpha-Ketoglutarate ↔ N-Succinyl-2-amino-6-ketopimelate + L-Glutamate
ReactionCard
SMPDB Reactions:
Thumb+L-Glutamic acid+Thumb → Thumb+Thumb
N-Succinyl-2-amino-6-ketopimelate + L-Glutamic acid + L-Glutamate → N-Succinyl-L,L-2,6-diaminopimelate + Oxoglutaric acid
ReactionCard
Thumb+L-Glutamic acid+Thumb → Thumb+Thumb
N-Acetyl-L-glutamate 5-semialdehyde + L-Glutamic acid + L-Glutamate → Oxoglutaric acid + N-Acetylornithine
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ← Thumb+Thumb
N-Acetylornithine + Oxoglutaric acid ← N-Acetyl-L-glutamate 5-semialdehyde + L-Glutamate
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
N-Acetylornithine + Oxoglutaric acid → N-Acetyl-L-glutamate 5-semialdehyde + L-Glutamate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000466alpha-KetoglutarateMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000675N-Acetyl-L-glutamate 5-semialdehydeMetaboCard
PAMDB000493N-AcetylornithineMetaboCard
PAMDB000835N-Succinyl-2-amino-6-ketopimelateMetaboCard
PAMDB000836N-Succinyl-L,L-2,6-diaminopimelateMetaboCard
PAMDB000623Oxoglutaric acidMetaboCard
GO Classification:
Function
binding
catalytic activity
cofactor binding
pyridoxal phosphate binding
transaminase activity
transferase activity
transferase activity, transferring nitrogenous groups
Process
arginine metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
glutamine family amino acid metabolic process
metabolic process
Gene Properties
Locus tag: PA0895
Strand: +
Entrez Gene ID: 878207
Accession: NP_249586.1
GI: 15596092
Sequence start: 977910
Sequence End: 979130
Sequence Length: 1220
Gene Sequence: 
>PA0895
ATGTCCGCTCCCCATGCGCAGGTAGAACGTGCCGATTTCGACCGGTATATGGTCCCCAACTACGCCCCCGCCGCCTTCATTCCGGTGCGAGGCGAGGGATCGCGCGTCTGGGACCAGAGCGGCCGCGAACTGATCGATTTCGCCGGCGGCATCGCCGTGACCTCCCTGGGCCACGCGCATCCGGCGCTGGTCAAGGCGCTCACCGAGCAGGCCCAGCGCATCTGGCACGTTTCCAACGTCTTCACTAACGAGCCGGCCCTGCGCCTGGCGCGCAAGCTGGTGGACGCCACCTTCGCCGAGCGGGTGTTCCTCGCCAATTCCGGCGCCGAAGCCAACGAGGCGGCCTTCAAGCTGGCTCGCCGCTACGCCAACGATGTCTACGGCCCGCAGAAGTACGAGATCATCGCCGCCAGCAACAGCTTCCACGGGCGCACCCTGTTCACCGTCAACGTCGGCGGCCAGCCGAAGTATTCCGATGGCTTCGGGCCCAAGTTCGAGGGTATCACCCACGTTCCCTACAACGACCTGGAAGCGCTGAAGGCGGCGATCTCCGACAAGACCTGCGCCGTGGTGCTGGAACCGATCCAGGGCGAGGGCGGCGTGCTGCCGGCGCAGCAGGCCTACCTGGAAGGGGCGCGCAAGCTGTGCGACGAGCACAACGCGCTGCTGGTCTTCGACGAGGTCCAGAGCGGCATGGGCCGGGTCGGCGAGCTGTTCGCCTACATGCACTACGGCGTGGTCCCGGACATCCTCTCCAGCGCCAAGAGCCTGGGCGGCGGCTTCCCTATCGGTGCGATGCTGACCACCGGCGAGATCGCCAAGCACCTGTCGGTCGGCACCCACGGCACCACCTACGGCGGCAACCCGCTGGCGTCGGCGGTGGCCGAGGCGGCGCTGGACGTGATCAATACCCCGGAAGTGCTGGATGGCGTGAAGGCCAAGCATGAGCGCTTCAAGTCCCGCCTGCAGAAGATCGGCCAGGAGTACGGCATCTTCGACGAGATCCGCGGCATGGGCCTGCTGATCGGCGCGGCGCTGACCGACGAGTGGAAGGGCAAGGCCAGGGATGTGCTCAACGCCGCCGAGAAAGAGGCGGTCATGGTGCTCCAGGCCAGCCCGGACGTGGTGCGCTTCGCGCCGAGCCTGGTGATCGACGACGCCGAGATCGACGAAGGCCTGGAGCGCTTCGAGCGCGCCGTGGCCAAGCTGGTCCGCGGCTGA
Protein Properties
Protein Residues: 406
Protein Molecular Weight: 43.7 kDa
Protein Theoretical pI: 5.8
Hydropathicity (GRAVY score): -0.087
Charge at pH 7 (predicted): -7.4
Protein Sequence: 
>PA0895
MSAPHAQVERADFDRYMVPNYAPAAFIPVRGEGSRVWDQSGRELIDFAGGIAVTSLGHAHPALVKALTEQAQRIWHVSNVFTNEPALRLARKLVDATFAERVFLANSGAEANEAAFKLARRYANDVYGPQKYEIIAASNSFHGRTLFTVNVGGQPKYSDGFGPKFEGITHVPYNDLEALKAAISDKTCAVVLEPIQGEGGVLPAQQAYLEGARKLCDEHNALLVFDEVQSGMGRVGELFAYMHYGVVPDILSSAKSLGGGFPIGAMLTTGEIAKHLSVGTHGTTYGGNPLASAVAEAALDVINTPEVLDGVKAKHERFKSRLQKIGQEYGIFDEIRGMGLLIGAALTDEWKGKARDVLNAAEKEAVMVLQASPDVVRFAPSLVIDDAEIDEGLERFERAVAKLVRG
References
External Links:
Resource Link
Genome ID: PA0895
Entrez Gene ID: 878207
NCBI Protein ID: 15596092
General Reference: PaperBLAST - Find papers about PA0895 and its homologs