| Identification |
| Name: |
tRNA N6-adenosine threonylcarbamoyltransferase |
| Synonyms: |
Not Available |
| Gene Name: |
tsaD |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
threonylcarbamoyladenosine biosynthetic process |
| Specific Function: |
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. May also be involved in the metabolism of glycated proteins, but does not show sialoglycoprotease activity against glycophorin A. |
| Cellular Location: |
Not Available |
| KEGG Pathways: |
Not Available |
| KEGG Reactions: |
|
 | ↔ |  |
| |
|
| SMPDB Reactions: |
Not Available |
| PseudoCyc/BioCyc Reactions: |
|
| ↔ | |
| | | |
|
| Complex Reactions: |
Not Available |
| Transports: |
Not Available |
| Metabolites: |
| PAMDB ID | Name | View |
|---|
| PAMDB000014 | Adenosine monophosphate | MetaboCard | | PAMDB004367 | L-Threonylcarbamoyladenylate | MetaboCard |
|
| GO Classification: |
| Function |
|---|
| cytosol | | glycoprotein binding | | identical protein binding | | iron ion binding | | metalloendopeptidase activity | | peptidase activity | | proteolysis | | threonylcarbamoyladenosine biosynthetic process | | transferase activity, transferring acyl groups other than amino-acyl groups |
|
| Gene Properties |
| Locus tag: |
PA0580 |
| Strand: |
+ |
| Entrez Gene ID: |
882271 |
| Accession: |
NP_249271.1 |
| GI: |
15595777 |
| Sequence start: |
639316 |
| Sequence End: |
640341 |
| Sequence Length: |
1025 |
| Gene Sequence: |
>PA0580
ATGCGCGTGCTGGGACTGGAAACGTCCTGCGACGAAACCGGCGTCGCCCTTTACGACAGCGAACGCGGCCTGCTGGCCGACGCGCTGTTCAGTCAGATCGACCTCCATCGCGTCTACGGCGGCGTCGTGCCCGAGCTGGCCTCGCGCGACCACGTCAAGCGCATGCTGCCGCTGATCCGCCAGGTGCTCGACGAGTCCGGCTGCACGCCGGCGGATATCGACGCGATCGCCTATACCGCCGGTCCCGGCCTGGTCGGCGCCCTGCTGGTGGGGGCTTCCTGTGCCCAGGCGATGGCCTTCGCCTGGGGCGTGCCGGCGGTCGGCGTGCACCACATGGAAGGGCACCTGCTGGCGCCGATGCTGGAAGAGCAGCCACCGCGGTTCCCGTTCGTCGCCTTGCTGGTTTCCGGCGGTCACACCCAGTTGGTGCGGGTGGACGGTATCGGCCGCTACCAGTTGCTTGGCGAATCGGTGGACGATGCCGCCGGCGAAGCCTTCGACAAGACCGCCAAGCTGATCGGCCTGGGCTATCCCGGTGGTCCGGAAATCGCCCGCCTGGCGGAGCGCGGCACTCCTGGCCGCTTCGTGTTCCCGCGGCCGATGACCGATCGCCCCGGCCTGGACTTCAGCTTCAGCGGGCTCAAGACCTTTACCCTGAACACCTGGCAGCGTTGCGTCGAGGCCGGCGACGACAGCGAGCAGACCCGCTGCGACATCGCCCTGGCGTTCCAGACCGCGGTGGTCGAGACCCTGCTGATCAAGTGCCGTCGCGCCTTGAAGCAGACCGGCCTGAAGAACCTGGTGATCGCCGGCGGCGTCAGCGCCAACCAGGCGCTGCGCAGCGGCCTGGAAAAGATGCTCGGCGAAATGAAGGGGCAGGTGTTCTACGCCCGCCCGCGCTTCTGCACCGACAATGGCGCGATGATCGCCTACGCCGGCTGCCAGCGCCTGCTCGCCGGCCAGCATGACGGCCCGGCGATCAGCGTCCAGCCGCGCTGGCCGATGGAGTCGCTGCCGGCGGTCTGA |
| Protein Properties |
| Protein Residues: |
341 |
| Protein Molecular Weight: |
36.6 kDa |
| Protein Theoretical pI: |
6.16 |
| Hydropathicity (GRAVY score): |
0.058 |
| Charge at pH 7 (predicted): |
-3.56 |
| Protein Sequence: |
>PA0580
MRVLGLETSCDETGVALYDSERGLLADALFSQIDLHRVYGGVVPELASRDHVKRMLPLIRQVLDESGCTPADIDAIAYTAGPGLVGALLVGASCAQAMAFAWGVPAVGVHHMEGHLLAPMLEEQPPRFPFVALLVSGGHTQLVRVDGIGRYQLLGESVDDAAGEAFDKTAKLIGLGYPGGPEIARLAERGTPGRFVFPRPMTDRPGLDFSFSGLKTFTLNTWQRCVEAGDDSEQTRCDIALAFQTAVVETLLIKCRRALKQTGLKNLVIAGGVSANQALRSGLEKMLGEMKGQVFYARPRFCTDNGAMIAYAGCQRLLAGQHDGPAISVQPRWPMESLPAV |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA0580 and its homologs
|
