Tryptophan synthase alpha chain (PA0035)

Identification
Name: Tryptophan synthase alpha chain
Synonyms: Not Available
Gene Name: trpA
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb
Indole + L-Serine → Water + L-Tryptophan
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
Indoleglycerol phosphate + L-Serine → D-Glyceraldehyde 3-phosphate + Water + L-Tryptophan
ReactionCard
Thumb → Thumb+Thumb
Indoleglycerol phosphate → D-Glyceraldehyde 3-phosphate + Indole
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
L-Serine + Indole ↔ L-Tryptophan + Water
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Serine + Indoleglycerol phosphate ↔ L-Tryptophan + D-Glyceraldehyde 3-phosphate + Water
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
Indoleglycerol phosphate + L-Serine → L-Tryptophan + Water + D-Glyceraldehyde 3-phosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Serine + Indoleglycerol phosphate + Indole ↔ L-Tryptophan + D-Glyceraldehyde 3-phosphate + Water
ReactionCard
SMPDB Reactions:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate+Thumb → D-Glyceraldehyde 3-phosphate+Thumb+Thumb
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate → D-Glyceraldehyde 3-phosphate + Indole + D-Glyceraldehyde 3-phosphate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
Indole + L-Serine → Water + L-Tryptophan
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
Indoleglycerol phosphate + L-Serine → D-Glyceraldehyde 3-phosphate + Water + L-Tryptophan
ReactionCard
Thumb → Thumb+Thumb
Indoleglycerol phosphate → D-Glyceraldehyde 3-phosphate + Indole
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
Indoleglycerol phosphate + L-Serine → L-Tryptophan + Water + D-Glyceraldehyde 3-phosphate
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+glyceraldehyde 3-phosphate+Thumb
L-Serine + Indoleglycerol phosphate → L-Tryptophan + glyceraldehyde 3-phosphate + Water
ReactionCard
Thumb+Thumb → Thumb+glyceraldehyde 3-phosphate+Thumb
L-Serine + Indoleglycerol phosphate → L-Tryptophan + glyceraldehyde 3-phosphate + Water
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB006319(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphateMetaboCard
PAMDB000257D-Glyceraldehyde 3-phosphateMetaboCard
PAMDB000181IndoleMetaboCard
PAMDB001007Indoleglycerol phosphateMetaboCard
PAMDB000077L-SerineMetaboCard
PAMDB000203L-TryptophanMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
carbon-oxygen lyase activity
catalytic activity
hydro-lyase activity
lyase activity
tryptophan synthase activity
Process
cellular amino acid and derivative metabolic process
cellular amino acid derivative metabolic process
cellular biogenic amine metabolic process
cellular metabolic process
indolalkylamine metabolic process
metabolic process
tryptophan metabolic process
Gene Properties
Locus tag: PA0035
Strand: -
Entrez Gene ID: 879479
Accession: NP_248725.1
GI: 15595233
Sequence start: 37087
Sequence End: 37893
Sequence Length: 806
Gene Sequence: 
>PA0035
ATGAGCCGCCTGCAGACCCGCTTCGCCCAGCTCAAGCAGGAAAACCGCGCCGCCCTGGTGACCTTCGTCACCGCCGGCGACCCGGACTACGCGTCTTCCCTGGAAATCCTCAAAGGCCTGCCGGCGGCCGGAGCCGACGTGATCGAACTGGGCATGCCGTTCACCGATCCGATGGCGGACGGCCCGGCCATCCAGTTGGCCAACATCCGCGCCCTGGACGGCGGCCAGACCCTGGCCAGGACGTTGCAGATGGTCCGCGAATTCCGCAGCGGCGACAGCGAGACGCCCCTGGTGCTGATGGGCTACTTCAACCCGATCCACCACTACGGCGTCGAACGCTTCATCGCCGAGGCGAAGGAGGTGGGAGTGGACGGCCTGATCGTGGTCGACCTGCCGCCGGAGCACAACGAAGACCTCTGCCACCCGGCCCAGGCCGCCGGCATCGACTTCATCCGCCTGACCACCCCGACCACCGGCGACCAGCGCCTGCCGACGGTGCTAGAAGGCAGTTCCGGGTTCGTCTACTACGTGTCGGTGGCCGGCGTCACCGGCGCCAACGCGGCGACCCTGGAACACGTCGAGGAAGCGGTGGCGCGCCTGCGCCGGCATACCGACCTGCCGATCGGTATCGGCTTCGGCATCCGCAGCGCCGAACACGCCGCCGCGGTCGCGCGGTTGGCCGACGGCGTGGTGGTCGGCTCGGCGCTGATCGACCGGATCGCCAAGGCCCGCGACAATGCCCAGGCGGTCAAGGATGTCCTCGCCCTGTGCGGCGAGCTGGCCGAAGGCGTGCGCAACGCACGCTGA
Protein Properties
Protein Residues: 268
Protein Molecular Weight: 28.5 kDa
Protein Theoretical pI: 5
Hydropathicity (GRAVY score): 0.061
Charge at pH 7 (predicted): -8.37
Protein Sequence: 
>PA0035
MSRLQTRFAQLKQENRAALVTFVTAGDPDYASSLEILKGLPAAGADVIELGMPFTDPMADGPAIQLANIRALDGGQTLARTLQMVREFRSGDSETPLVLMGYFNPIHHYGVERFIAEAKEVGVDGLIVVDLPPEHNEDLCHPAQAAGIDFIRLTTPTTGDQRLPTVLEGSSGFVYYVSVAGVTGANAATLEHVEEAVARLRRHTDLPIGIGFGIRSAEHAAAVARLADGVVVGSALIDRIAKARDNAQAVKDVLALCGELAEGVRNAR
References
External Links:
Resource Link
Genome ID: PA0035
Entrez Gene ID: 879479
NCBI Protein ID: 15595233
General Reference: PaperBLAST - Find papers about PA0035 and its homologs