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Record Information |
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| Version |
1.0 |
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| Update Date |
1/22/2018 12:54:54 PM |
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Metabolite ID | PAMDB120551 |
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Identification |
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| Name: |
baicalein |
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| Description: | A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7. |
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Structure |
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| Synonyms: | - 5,6,7-Trihydroxyflavone
- Baicalein
- baicalein (OLD)
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Chemical Formula: |
C15H10O5 |
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| Average Molecular Weight: |
270.241 |
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| Monoisotopic Molecular
Weight: |
270.05283 |
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| InChI Key: |
FXNFHKRTJBSTCS-UHFFFAOYSA-N |
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| InChI: | InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H |
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| CAS
number: |
192224-98-9 |
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| IUPAC Name: | 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one |
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Traditional IUPAC Name: |
6-({4,5-dihydroxy-6-methyl-3-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl}oxy)-5-hydroxy-7-methoxy-2-phenylchromen-4-one |
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| SMILES: | C1(C=CC(=CC=1)C2(=CC(=O)C3(=C(O2)C=C(O)C(O)=C(O)3))) |
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Chemical Taxonomy |
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Taxonomy Description | This compound belongs to the class of organic compounds known as flavonoid o-glycosides. These are compounds containing a carbohydrate moiety which is O-glycosidically linked to the 2-phenylchromen-4-one flavonoid backbone. |
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Kingdom |
Organic compounds |
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| Super Class | Phenylpropanoids and polyketides |
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Class |
Flavonoids |
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| Sub Class | Flavonoid glycosides |
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Direct Parent |
Flavonoid O-glycosides |
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| Alternative Parents |
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| Substituents |
- Flavonoid o-glycoside
- Flavonoid-6-o-glycoside
- Methoxyflavonoid skeleton
- 7-methoxyflavonoid-skeleton
- Hydroxyflavonoid
- Flavone
- 5-hydroxyflavonoid
- Phenolic glycoside
- O-glycosyl compound
- Glycosyl compound
- Disaccharide
- Chromone
- 1-benzopyran
- Methoxyphenol
- Benzopyran
- Anisole
- Pyranone
- Alkyl aryl ether
- Benzenoid
- Pyran
- Oxane
- Saccharide
- Monocyclic benzene moiety
- Heteroaromatic compound
- Vinylogous acid
- Secondary alcohol
- Polyol
- 1,2-diol
- Oxacycle
- Organoheterocyclic compound
- Ether
- Acetal
- Hydrocarbon derivative
- Organooxygen compound
- Alcohol
- Aromatic heteropolycyclic compound
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| Molecular Framework |
Aromatic heteropolycyclic compounds |
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| External Descriptors |
Not Available |
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Physical Properties |
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| State: |
Not Available |
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| Charge: | 0 |
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Melting point: |
238 - 239.3 °C |
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| Experimental Properties: |
| Property | Value | Reference |
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| Melting Point | 238 - 239.3 °C | Not Available | | Boiling Point | Not Available | Not Available | | Water Solubility | Not Available | Not Available | | LogP | Not Available | Not Available |
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| Predicted Properties |
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Biological Properties |
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| Cellular Locations: |
Not Available |
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| Reactions: | |
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Pathways: |
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Spectra |
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| Spectra: |
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References |
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| References: |
- Nagashima S, Hirotani M, Yoshikawa T (2000)Purification and characterization of UDP-glucuronate: baicalein 7-O-glucuronosyltransferase from Scutellaria baicalensis Georgi. cell suspension cultures. Phytochemistry 53, Pubmed: 10724177
- Huang Y, Tsang SY, Yao X, Chen ZY (2005)Biological properties of baicalein in cardiovascular system. Current drug targets. Cardiovascular & haematological disorders 5, Pubmed: 15853750
- Sithisarn P, Michaelis M, Schubert-Zsilavecz M, Cinatl J (2013)Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells. Antiviral research 97, Pubmed: 23098745
- Oh SB, Park HR, Jang YJ, Choi SY, Son TG, Lee J (2013)Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by ?-ray radiation. British journal of pharmacology 168, Pubmed: 22891631
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| Synthesis Reference: |
Not Available |
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| Material Safety Data Sheet (MSDS) |
Not Available |
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Links |
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| External Links: |
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