Record Information |
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Version |
1.0 |
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Update Date |
1/22/2018 12:54:54 PM |
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Metabolite ID | PAMDB110105 |
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Identification |
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Name: |
orotidine 5'-phosphate |
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Description: | Trianion of orotidine 5'-phosphate arising from deprotonation of carboxylic acid and phosphate functions. |
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Structure |
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Synonyms: | - uridine-5\'-phosphate biosynthesis
- de novo biosynthesis of uridine-5\'-phosphate
de novo biosynthesis of uridine-5\'-monophosphate'- WIDTH
- 500);" onmouseout="return nd();"> UMP biosynthesis
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orotidine 5'-phosphate + H+ → CO2 + UMP
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Chemical Formula: |
C10H10N2O11P
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Average Molecular Weight: |
365.17 |
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Monoisotopic Molecular
Weight: |
368.0256957808 |
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InChI Key: |
KYOBSHFOBAOFBF-XVFCMESISA-K |
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InChI: |
InChI=1S/C10H13N2O11P/c13-5-1-3(9(16)17)12(10(18)11-5)8-7(15)6(14)4(23-8)2-22-24(19,20)21/h1,4,6-8,14-15H,2H2,(H,16,17)(H,11,13,18)(H2,19,20,21)/p-3/t4-,6-,7-,8-/m1/s1 |
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CAS
number: |
2149-82-8 |
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IUPAC Name: | 2,6-dioxo-3-(5-O-phosphonato-β-D-ribofuranosyl)-1,2,3,6-tetrahydropyrimidine-4-carboxylate |
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Traditional IUPAC Name: |
6-carboxy-5'-uridylic acid |
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SMILES: | C(OP(=O)([O-])[O-])C1(OC(C(O)C(O)1)N2(C(C(=O)[O-])=CC(=O)NC(=O)2)) |
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Chemical Taxonomy |
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Taxonomy Description | This compound belongs to the class of chemical entities known as pyrimidine ribonucleoside monophosphates. These are pyrimidine ribobucleotides with monophosphate group linked to the ribose moiety. |
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Kingdom |
Chemical entities |
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Super Class | Organic compounds |
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Class |
Nucleosides, nucleotides, and analogues |
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Sub Class | Pyrimidine nucleotides |
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Direct Parent |
Pyrimidine ribonucleoside monophosphates |
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Alternative Parents |
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Substituents |
- Pyrimidine ribonucleoside monophosphate
- Pentose-5-phosphate
- Pentose phosphate
- Glycosyl compound
- N-glycosyl compound
- Monosaccharide phosphate
- Pentose monosaccharide
- Pyrimidine-6-carboxylic acid or derivatives
- Pyrimidine-6-carboxylic acid
- Hydropyrimidine carboxylic acid derivative
- Monoalkyl phosphate
- Pyrimidone
- Hydropyrimidine
- Monosaccharide
- Organic phosphoric acid derivative
- Alkyl phosphate
- Phosphoric acid ester
- Pyrimidine
- Heteroaromatic compound
- Oxolane
- Vinylogous amide
- Secondary alcohol
- Urea
- Lactam
- 1,2-diol
- Organoheterocyclic compound
- Azacycle
- Carboxylic acid derivative
- Carboxylic acid
- Monocarboxylic acid or derivatives
- Oxacycle
- Organic oxide
- Organopnictogen compound
- Organic oxygen compound
- Alcohol
- Hydrocarbon derivative
- Organooxygen compound
- Organic nitrogen compound
- Organonitrogen compound
- Aromatic heteromonocyclic compound
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Molecular Framework |
Aromatic heteromonocyclic compounds |
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External Descriptors |
- pyrimidine ribonucleoside 5'-monophosphate (CHEBI:15842 )
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Physical Properties |
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State: |
Solid |
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Charge: | -3 |
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Melting point: |
Not Available |
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Experimental Properties: |
Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties |
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Biological Properties |
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Cellular Locations: |
Not Available |
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Reactions: | |
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Pathways: |
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Spectra |
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Spectra: |
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References |
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References: |
- Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. [19212411 ]
- Traut TW: Uridine-5'-phosphate synthase: evidence for substrate cycling involving this bifunctional protein. Arch Biochem Biophys. 1989 Jan;268(1):108-15. [2912371 ]
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Synthesis Reference: |
Ueda, Tohru; Yamamoto, Miyako; Yamane, Akira; Imazawa, Masaoki; Inoue, Hideo. Nucleosides and nucleotides. XXIII. Conversion of uridine nucleotides to the 6-cyano derivatives: synthesis of orotidylic acid. Journal of Carbohydrates, Nucleosides, Nucleotides (1978), 5(3), 261-71. |
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Material Safety Data Sheet (MSDS) |
Not Available |
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Links |
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External Links: |
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